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The Life History of 21 Breast Cancers

Elsevier (opens in a new tab)

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

It is found that pancreatic cancer acquires rearrangements indicative of telomere dysfunction and abnormal cell-cycle control, namely dysregulated G1-to-S-phase transition with intact G2–M checkpoint, and phylogenetic trees across metastases show organ-specific branches.
Nature (opens in a new tab)

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

The myeloma genome is heterogeneous across the cohort, and exhibits diversity in clonal admixture and in dynamics of evolution, which may impact prognostic stratification, therapeutic approaches and assessment of disease response to treatment.
Springer (opens in a new tab)

Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry

The ISH method was superior to IHC, regarding robustness, sensitivity and specificity and will aid to further study expression levels of KCNJ3 in both malignant and physiological conditions.
BMJ Publishing Group (opens in a new tab)

Signatures of mutation and selection in the cancer genome

Structural signatures are derived that distinguish between homozygous deletions over recessive cancer genes and fragile sites and illustrate how structural signatures can be used to distinguish between the influences of mutation and selection in cancer genomes.
Nature (opens in a new tab)

Supplementary File 4

Two rearrangements were unique to BPM 24 and one of the published contig arrangements was present only in samples BPM24, RRIC 105 and RRIM 600 while all samples had the master circle arrangement for this locus.
PDF (opens in a new tab)

The topography of mutational processes in breast cancer genomes

It is demonstrated that mutational signatures are frequently associated with genomic architecture including nucleosome positioning and replication timing, as well as mutational processes of unknown aetiology.
Springer (opens in a new tab)

The DNA sequence and comparative analysis of human chromosome 20

Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.
Nature (opens in a new tab)

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

The largest sequencing study of osteosarcoma to date is presented, comprising 112 childhood and adult tumours encompassing all major histological subtypes and identifying distinct rearrangement profiles including a process characterized by chromothripsis and amplification.
Springer (opens in a new tab)

Supplementary file 2.

Tests were carried out in the N2 (wild-type) strain or in pha1(tm3671) mutants, as indicated, and all tests were performed with the UNC-70(TSMod).
Publisher (opens in a new tab)
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