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Systematic identification of genomic markers of drug sensitivity in cancer cells
It was found that mutated cancer genes were associated with cellular response to most currently available cancer drugs, and systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Mutational Processes Molding the Genomes of 21 Breast Cancers
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
The identification of inactivating mutations in two genes encoding enzymes involved in histone modification and NF2 mutations were found in non-VHL mutated ccRCC, and several other probable cancer genes were identified, indicating that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene.
Patterns of somatic mutation in human cancer genomes
More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
The landscape of cancer genes and mutational processes in breast cancer
Strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade are found, and multiple mutational signatures are observed, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides.
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
The protein coding exome is sequenced in a series of primary ccRCC and the identification of the SWI/SNF chromatin remodelling complex gene PBRM1 is reported as a second majorccRCC cancer gene, with truncating mutations in 41% (92/227) of cases.
The Life History of 21 Breast Cancers
A small-cell lung cancer genome with complex signatures of tobacco exposure
Using massively parallel sequencing technology, a small-cell lung cancer cell line, NCI-H209, is sequenced to explore the mutational burden associated with tobacco smoking and identifies a tandem duplication that duplicates exons 3–8 of CHD7 in frame, and another two lines carrying PVT1–CHD7 fusion genes, indicating that ChD7 may be recurrently rearranged in this disease.
A comprehensive catalogue of somatic mutations from a human cancer genome
The genomes of a malignant melanoma and a lymphoblastoid cell line from the same person are sequenced, providing the first comprehensive catalogue of somatic mutations from an individual cancer.