P. Futreal

Publications156
h-index82
Citations67,810
Highly Influential Citations3,272
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Mutations of the BRAF gene in human cancer
TLDR
BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.
View on Springer
Signatures of mutational processes in human cancer
TLDR
It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
View on Nature
A census of human cancer genes
TLDR
A 'census' of cancer genes is conducted that indicates that mutations in more than 1% of genes contribute to human cancer.
View on Nature
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
TLDR
With all genomic information recently updated to GRCh37, COSMIC integrates many diverse types of mutation information and is making much closer links with Ensembl and other data resources.
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Systematic identification of genomic markers of drug sensitivity in cancer cells
TLDR
It was found that mutated cancer genes were associated with cellular response to most currently available cancer drugs, and systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.
View on Nature
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
TLDR
The Genomics of Drug Sensitivity in Cancer (GDSC) provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.
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Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
View on Elsevier
The Catalogue of Somatic Mutations in Cancer (COSMIC)
TLDR
This unit describes the graphical system in detail, elaborating an example walkthrough and the many ways that the resulting information can be thoroughly investigated by combining data, respecializing the query, or viewing the results in different ways.
View on Wiley
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
TLDR
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer.
View on Nature
The cancer genome
TLDR
This work has shown that the complete DNA sequence of large numbers of cancer genomes will be possible to obtain and will provide a detailed and comprehensive perspective on how individual cancers have developed.
View on Nature
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