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Signatures of mutational processes in human cancer
It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1, and defined the extensive landscape of altered genes and pathways in HCC.
Mutational Processes Molding the Genomes of 21 Breast Cancers
Deciphering Signatures of Mutational Processes Operative in Human Cancer
Landscape of somatic mutations in 560 breast cancer whole genome sequences
This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
The repertoire of mutational signatures in human cancer
The substantial dataset size compared to previous analyses enabled discovery of new signatures, separation of overlapping signatures and decomposition of signatures into components that may represent associated, but distinct, DNA damage, repair and or replication mechanisms.
The Life History of 21 Breast Cancers
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
The myeloma genome is heterogeneous across the cohort, and exhibits diversity in clonal admixture and in dynamics of evolution, which may impact prognostic stratification, therapeutic approaches and assessment of disease response to treatment.
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71…
The Evolutionary History of Lethal Metastatic Prostate Cancer
Using whole-genome sequencing, multiple metastases arising from prostate tumours in ten patients are characterized and the complex patterns of metastatic spread are elucidate in detail and the development of resistance to androgen-deprivation therapy in prostate cancer is understood.