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zopolrestat

Known as: 3,4-Dihydro-4-oxo-3-((5-(trifluoromethyl)-2-benzothiazolyl)methyl)-1-phthalazineacetic Acid, 3,4-dihydro-4-oxo-3-((5-(trifluoromethyl)-2-benzothiazolyl)methyl)-1-phthalazine-acetic acid 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

BenzothiazolesEnzyme InhibitorsHypoglycemic AgentsPhthalazines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
The detrimental effects of acute hyperglycemia on myocardial glucose uptake.
2012
2012
The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells.
2011
2011
Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase.
2010
2010
Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells.
2004
2004
Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion.
2000
2000
High glucose enhances IL-1beta-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells.
Highly Cited
1998
Highly Cited
1998
Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts.
Alterations in glucose metabolism have been implicated in the cardiovascular complications of diabetes. Previous work in this… 
Highly Cited
1996
Highly Cited
1996
Specifically Targeted Modification of Human Aldose Reductase by Physiological Disulfides*
Aldose reductase is inactivated by physiological disulfides such as GSSG and cystine. To study the mechanism of disulfide-induced… 
Highly Cited
1995
Highly Cited
1995
Intracellular mechanism of high D-glucose-induced modulation of vascular cell proliferation.
1995
1995
Identification of an aldose reductase inhibitor site by affinity labeling.
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