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Contribution of polyol pathway to diabetes-induced oxidative stress.
- Stephen S Chung, E. Ho, K. Lam, Sookja K. Chung
- Biology, MedicineJournal of the American Society of Nephrology
- 1 August 2003
Results indicate that similar to the situation in the lens, AR is also the major contributor to hyperglycemia-induced oxidative stress in the nerve, although increased flux of glucose through the polyol pathway leads to diabetic lesions in both the lenses and nerve, the mechanisms may be different.
Fyn and p38 Signaling Are Both Required for Maximal Hypertonic Activation of the Osmotic Response Element-binding Protein/Tonicity-responsive Enhancer-binding Protein (OREBP/TonEBP)*
- B. Ko, A. Lam, A. Kapus, Lingzhi Fan, Sookja K. Chung, S. Chung
- BiologyThe Journal of Biological Chemistry
- 29 November 2002
It is shown that the transactivation domain of OREBP/TonEBP is the target of p38- and Fyn-mediated hypertonic activation, indicating a dual control in regulating the expression of the osmoprotective genes in mammalian cells.
Prenatal Immune Challenge Is an Environmental Risk Factor for Brain and Behavior Change Relevant to Schizophrenia: Evidence from MRI in a Mouse Model
The data indicate immune-associated environmental insults targeting early foetal development may have more extensive neurodevelopmental impact than identical insults in late prenatal life.
Caveolin‐1 regulates nitric oxide‐mediated matrix metalloproteinases activity and blood–brain barrier permeability in focal cerebral ischemia and reperfusion injury
J. Neurochem. (2012) 120, 147–156.
Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.
Findings indicate that AR is responsible for the early events in the pathogenesis of diabetic retinopathy, leading to a cascade of retinal lesions, including blood-retinal barrier breakdown, loss of pericytes, neuro- retinal apoptosis, glial reactivation, and neovascularization.
Endothelin-1 Overexpression Leads to Further Water Accumulation and Brain Edema after Middle Cerebral Artery Occlusion via Aquaporin 4 Expression in Astrocytic End-Feet
- A. C. Lo, Ann Y S Chen, Sookja K. Chung
- BiologyJournal of Cerebral Blood Flow and Metabolism
- 30 March 2005
The current data suggest that astrocytic ET-1 has deleterious effects on water homeostasis, cerebral edema and BBB integrity, which contribute to more severe ischemic brain injury.
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
It is shown that Cdk5-mediated phosphorylation of EndoB1 is essential for autophagy induction and neuronal loss in models of Parkinson’s disease.
Osmotic Response Element-binding Protein (OREBP) Is an Essential Regulator of the Urine Concentrating Mechanism*
Data indicate that in addition to vasopressin, OREBP is another essential regulator of the urine concentrating mechanism and develops progressive hydronephrosis soon after weaning, confirming the osmoprotective function of ORE BP implicated by the in vitro experiments.
Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice
The results indicated that chronic APN deficiency inactivated AMPK causing insulin desensitization and elicited AD-like pathogenesis in aged mice which also developed significant cognitive impairments and psychiatric symptoms.
Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1α Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice*
It is shown that transgenic mice with adipose tissue-selective expression of a dominant negative version of HIF1α developed more severe obesity and were more susceptible to high fat diet-induced glucose intolerance and insulin resistance compared with their wild type littermates.