FAQ

zonisamide

Known as: Zonisamida, 1,2-benzisoxazole-3-methanesulfonamide, 3-sulfamoylmethyl-1,2-benzisoxazole 
A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
02040608019792017

Related topics

Related topics

11 relations

Narrower (3)

AD 810CI 912Zonegran

Broader (3)

AnticonvulsantsAntioxidantsIsoxazoles
Antiepileptic AgentsDrug AllergyEpilepsies, PartialEpilepsy
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
zonisamide
Drug Allergy
Epilepsy
Antioxidants
Epilepsies, Partial
Sulfonamides

Papers overview

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2010
2010
Zonisamide: aspects in neuroprotection.
Zonisamide is widely used as an antiepileptic drug. Two studies published recently in Experimental Neurology focus on the drug's… (More)
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Highly Cited
2007
Highly Cited
2007
Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study.
OBJECTIVE To evaluate the efficacy, safety and tolerability of daily doses of 25, 50, and 100 mg of zonisamide (ZNS) administered… (More)
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Highly Cited
2005
Highly Cited
2005
Meta-analysis: pharmacologic treatment of obesity.
BACKGROUND In response to the increase in obesity, pharmacologic treatments for weight loss have become more numerous and more… (More)
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Highly Cited
2003
Highly Cited
2003
Zonisamide for weight loss in obese adults: a randomized controlled trial.
CONTEXT Zonisamide is a marketed antiepileptic drug that has serotonergic and dopaminergic activity in addition to blockade of… (More)
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2001
2001
Zonisamide has beneficial effects on Parkinson's disease patients.
Zonisamide (ZNS) is a generally well tolerated anticonvulsant that has beneficial effects on Parkinson's disease (PD). ZNS (300… (More)
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1997
1997
Zonisamide monotherapy in newly diagnosed infantile spasms.
PURPOSE We determined the short-term efficacy of zonisamide (ZNS) monotherapy in newly diagnosed patients with infantile spasms… (More)
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1996
1996
Mechanisms of T-type calcium channel blockade by zonisamide
We investigated the effects of zonisamide, a new antiepileptic drug, on voltage-dependent T-type calcium current (ICa) in… (More)
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1995
1995
Effects of zonisamide on dopaminergic system.
Effects of zonisamide (ZNS) on extracellular dopamine (DA), its precursor 3,4-dihydroxyphenylalanine (DOPA), its metabolites 3,4… (More)
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Highly Cited
1992
Highly Cited
1992
Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex.
We investigated the effect of zonisamide, a new antiepileptic drug, on voltage-dependent Ca2+ currents in cultured neurons of rat… (More)
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1987
1987
Zonisamide enhances slow sodium inactivation in Myxicola.
In voltage-clamped Myxicola giant axons Zonisamide (1,2-benzisoxazole-3-methanesulfonamide) caused a hyperpolarizing shift in the… (More)
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