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zonisamide

Known as: Zonisamida, 1,2-benzisoxazole-3-methanesulfonamide, 3-sulfamoylmethyl-1,2-benzisoxazole 
A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (3)

AD 810CI 912Zonegran

Broader (3)

AnticonvulsantsAntioxidantsIsoxazoles
Antiepileptic AgentsDrug AllergyEpilepsies, PartialEpilepsy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat.
CASE DESCRIPTION A 2-year-old neutered male domestic shorthair cat was evaluated for sudden onset of cluster seizures. CLINICAL… 
2014
2014
Weight changes in obese adults 6‐months after discontinuation of double‐blind zonisamide or placebo treatment
We evaluated weight changes in obese patients at 6‐months after they ended participation in a 12‐month randomised controlled… 
2012
2012
Polypharmacology in drug discovery
List of contributors. Preface. Introduction: the case for polypharmacology Andrew L. Hopkins Part A: Polypharmacology a safety… 
2011
2011
Zonisamide-related erectile dysfunction.
1 Brotto LA, Gorzalka BB. Melatonin enhances sexual behavior in the male rat. Physiol Behav 2000;68:483–6. 2 Drago F, Busa L… 
2008
2008
Development and validation of a capillary electrophoresis method for determination of oxcarbazepine and zonisamide in pharmaceuticals
A simple, rapid capillary electrophoretic (CE) method has been evaluated and validated for determination of two newer… 
Highly Cited
2007
Highly Cited
2007
Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.
OBJECTIVE Zonisamide and bupropion have been investigated for weight reduction in obese adults. We conducted a preliminary study… 
2003
2003
Treatment of Chronic Pain with Zonisamide
▪ Abstract:  Mechanistic similarities underlying neuropathic pain and epilepsy suggest that anticonvulsants can be used for… 
1995
1995
Free radical scavenging activity of zonisamide and its inhibitory effect on lipid peroxide formation in iron-induced epileptogenic foci of rats
We evaluated the scavenging action of zonisamide, an antiepileptic agent, on hydroxyl radicals, superoxide radicals, 1,1-diphenyl… 
1994
1994
Serum Zonisamide Concentration in Fresh Cases of Childhood Epilepsy Following Zonisamide Monotherapy.
15歳未満の小児てんかん新鮮例47例にZNS単剤投与し, 血中ZNS総濃度および遊離型濃度を継時的に測定し次の結果を得た。1. 年齢を2歳未満, 2歳以上5歳未満, 5歳以上10歳未満, 10歳以上の4群に分け, 血中濃度/投与量比を比較すると, !0… 
1980
1980
Differential antagonisms of anticonvulsants to various components of maximal seizures induced by electroshock or pentylenetetrazol in mice.
Effects of antiepileptic drugs on various components (TF: tonic extension of forelimb, TH: tonic extension of hindlimb and CL… 
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