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zonisamide

Known as: Zonisamida, 1,2-benzisoxazole-3-methanesulfonamide, 3-sulfamoylmethyl-1,2-benzisoxazole 
A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium… Expand
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (3)

AD 810CI 912Zonegran

Broader (3)

AnticonvulsantsAntioxidantsIsoxazoles
Antiepileptic AgentsDrug AllergyEpilepsies, PartialEpilepsy
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Papers overview

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Highly Cited
2007
Highly Cited
2007
Zonisamide improves motor function in Parkinson disease
Objective: To evaluate the efficacy, safety and tolerability of daily doses of 25, 50, and 100 mg of zonisamide (ZNS… Expand
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Review
2005
Review
2005
Mechanisms of action of antiepileptic drugs.
Gamma-aminobutyric acid (GABA), one of the main inhibitory neurotransmitters in the brain, interacts with three types of… Expand
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Review
2004
Review
2004
Zonisamide: chemistry, mechanism of action, and pharmacokinetics
Zonisamide is a synthetic 1,2-benzisoxazole-3-methanesulfonamide with anticonvulsant properties. The sulfamoyl group on… Expand
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Highly Cited
2003
Highly Cited
2003
Zonisamide for weight loss in obese adults: a randomized controlled trial.
CONTEXT Zonisamide is a marketed antiepileptic drug that has serotonergic and dopaminergic activity in addition to blockade of… Expand
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Highly Cited
2001
Highly Cited
2001
Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures
Background: Zonisamide is a sulfonamide antiepilepsy drug with sodium and calcium channel–blocking actions. Experience in Japan… Expand
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Highly Cited
2001
Highly Cited
2001
Language Disturbances as Side Effects of Topiramate and Zonisamide Therapy
Reversible side effects of two sulfa-containing antiepileptic drugs (AEDs), topiramate (TPM) and zonisamide (ZNS), are reported… Expand
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Highly Cited
1995
Highly Cited
1995
Effects of zonisamide on dopaminergic system
Effects of zonisamide (ZNS) on extracellular dopamine (DA), its precursor 3,4-dihydroxyphenylalanine (DOPA), its metabolites 3,4… Expand
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Highly Cited
1993
Highly Cited
1993
Zonisamide for add-on treatment of refractory partial epilepsy: a European double-blind trial
The new antiepileptic drug zonisamide was evaluated in a European multicenter parallel-group double-blind trial as add-on… Expand
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Highly Cited
1992
Highly Cited
1992
Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex
We investigated the effect of zonisamide, a new antiepileptic drug, on voltage-dependent Ca2+ currents in cultured neurons of rat… Expand
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Review
1990
Review
1990
Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.
s, 18th International Epilepsy Congress, p. 90, New Delhi, India, 1989a. KALVIAINEN, R., SIvENIUS, J., YLINEN, A., AND RIEKKINEN… Expand
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