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zindotrine

Known as: 8-methyl-6-(1-piperidinyl)-1,2,4-triazolo(4,3-b)pyridazine, 8-methyl-6-piperidino-s-triazolo (4,3-b)Pyridazine 
National Institutes of Health

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MDL 257

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Pyridazines

Papers overview

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2018
2018
Catalyst-Free Synthesis of Fused Triazolo-Diazepino[5,6-b]Quinoline Derivatives via a Sequential Ugi-4CR–Nucleophilic Substitution–Intramolecular Click Reaction
Abstract A convenient, post-transformational reaction has been developed for the construction of highly diversified quinoline… 
2013
2013
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
2013
2013
Synthesis, Structural Study and Biological Activity of Bridgehead Nitrogen Containing Triazolo-thiadiazine Derivatives
A facile synthesis of 6,7-di-[substituted]-phenyl-3-pyridin-4-yl-5H-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazines have been… 
2010
2010
A novel rearrangement of fluorescent human thymidylate synthase inhibitor analogues in ESI tandem mass spectrometry
2007
2007
Microwave‐Assisted Synthesis and Biological Activity of 3‐Alkyl/aryl‐6‐ (1‐chloro‐3,4‐dihydronaphth‐2‐yl)‐5,6‐dihydro‐s‐triazolo[3,4‐b] [1,3,4]thiadiazoles.
3-Alkyl/aryl-6-(l-chloro-3,4-dihydronaphth-2-yl)-5,6-dihydro-s-triazolo[3,4-b][1,3,4]thiadiazoles 3 have been synthesised by the… 
2007
2007
Novel Regioselective Formation of S- and N-Hydroxyl-Alkyls of 5-(3-Chlorobenzo[b]Thien-2-yl)-3-Mercapto-4H-1,2,4-Triazole and A Facile Synthesis of Triazolo-Thiazoles and Thiazolo-Triazoles. Role of…
Regioselective alkylation of 5-(3-chlorobenzo[b]thien-2-yl)-4H-1,2,4-triazole (1) with hydroxy alkylating agents 2, 3, 13, and… 
2006
2006
First synthesis of 1,2,3-triazolo-linked (1,6)-alpha-D-oligomannoses (triazolomannoses) by iterative Cu(I)-catalyzed alkyne-azide cycloaddition.
The iterative copper(I)-catalyzed cycloaddition (rt or microwave) between an ethynyl alpha-C-mannoside and alkyl 6-azido-alpha-C… 
2006
2006
Microwave-Mediated Synthesis of Some Novel Heterocycles Containing Thiazole, Oxazole, Thiazine, Oxazine, Thiadiazine and Triazolo-thiadiazine Moiety.
5,5-Dimethyl cyclohexane-1,3-dione 1 has been brominated to yield 2-bromo-5,5-dimethyl cyclohexane-1,3-dione 2 which on further… 
1992
1992
Synthesis of carboxyalkylthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity.
3-Carboxyalkylthio derivatives of 5-alkoxyphenyl-1,2,4-triazole were prepared, performing some substitutions both on carboxyalkyl… 
1977
1977
Metabolism of budralazine, a new antihypertensive agent. II. Metabolic pathways of budralazine in rats.
The metabolic pathways of budralazine were studied in vivo and in vitro experiments and characterized as follows ; 1) 3-methyl-s… 
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