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Evaluation of Microsatellite Markers for Genetic Diversity Analysis among Sugarcane Species and Commercial Hybrids
TLDR
The UGSM and SCM yielded a higher mean number of alleles per locus and superior polymorphism information content (PIC) values than the sugarcane genomic markers (SGM); the number of amplified fragments ranged from 4 (UGSM312) to 14 (UG SM667) indicating that high polyploidy and hetrozygosity exist in sugarcanes. Expand
Stacking Interactions between Carbohydrate and Protein Quantified by Combination of Theoretical and Experimental Methods
TLDR
Observed results suggest that in this and similar cases the carbohydrate-receptor interaction can be driven mainly by a dispersion interaction. Expand
In Silico Mutagenesis and Docking Study of Ralstonia solanacearum RSL Lectin: Performance of Docking Software To Predict Saccharide Binding
TLDR
The Ala40 residue was found to be the most interesting residue for mutagenesis and can affect the selectivity and/or affinity and the docking software used performs better for high affinity binders and fails to place the binding affinities in the correct order. Expand
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain
TLDR
It is suggested that a juxtamembrane region of PGAP4 accommodates various GPI-anchored proteins, presenting their acceptor residue toward the catalytic center, and elucidate the initial step of G PI-GalNAc biosynthesis. Expand
Evaluation of Selected Classical Force Fields for Alchemical Binding Free Energy Calculations of Protein-Carbohydrate Complexes.
TLDR
The level of accuracy provided by GLYCAM06j is sufficient to discriminate potent, moderate, and weak binders, a goal that has been difficult to achieve through other scoring approaches, and could find useful applications in carbohydrate-based drug and vaccine developments. Expand
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
TLDR
The in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick's disease, PSP, and corticobasal degeneration patients who underwent PET scans. Expand
Tau Filaments and the Development of Positron Emission Tomography Tracers
TLDR
An overview of Tau filaments and their positron emission tomography ligands is provided to conclude that the pathological pathway is central to the development of all cases of disease, even if there are multiple reasons for Tau assembly. Expand
Enhanced conformational sampling of carbohydrates by Hamiltonian replica-exchange simulation.
TLDR
The biasing potential-based replica-exchange molecular dynamics (BP-REMD) method provided a significantly improved sampling of relevant conformational states compared with standard continuous MD simulations, with modest computational costs. Expand
Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan*
TLDR
It is found that bisecting GlcNAc, a branching sugar residue in N-glycan, suppresses the biosynthesis of various types of terminal epitopes inN-glycans, including fucose, sialic acid and human natural killer-1. Expand
3D structural analysis of protein O‐mannosyl kinase, POMK, a causative gene product of dystroglycanopathy
TLDR
The crystal structures of the POMK catalytic domain in the absence and presence of an ATP analogue and O‐mannosylated glycopeptide are reported and mutations in this protein causing muscular dystrophies can now be rationalized. Expand
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