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Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen.
TLDR
In vivo efficacy was assessed on the rabbit eye after induction of an ocular trauma (paracentesis), and an inhibition of the miotic response to the surgical trauma was achieved, comparable to a control aqueous eye-drop formulation, even though a lower concentration of free drug in the conjunctival sac was reached from the nanoparticle system. Expand
PLA/PLGA nanoparticles for sustained release of docetaxel.
TLDR
Kinetic experiments demonstrated that the release process of DTX form nanospheres is affected by the molecular weight of the employed polymers, and suggested that DTX was molecularly dispersed in the polymeric matrices. Expand
Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application.
TLDR
In vivo anti-inflammatory efficacy was assessed in the rabbit eye after induction of an ocular trauma and an inhibition of the miotic response to the surgical trauma comparable to a control eye-drop formulation was obtained, even though an actual lower concentration of free drug in the conjunctival sac was achieved from the nanoparticles. Expand
Ocular tolerability of Eudragit RS100 and RL100 nanosuspensions as carriers for ophthalmic controlled drug delivery.
TLDR
Polymer nanoparticles appeared to be avoiding of any irritant effect on cornea, iris, and conjunctiva up to 24 h after application, thus appearing to be a suitable inert carrier for ophthalmic drug delivery. Expand
Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development
TLDR
This review describes the analytical methods used to look at the interactions among bioactive compounds with biological membrane models, with a particular accent on the calorimetric techniques. Expand
Biocompatibility of poly(D,L-lactide-co-glycolide) nanoparticles conjugated with alendronate.
TLDR
Results demonstrated that PLGA-ALE NPs had an acceptable degree of blood compatibility and were not cytotoxic; therefore, they may be considered suitable for intravenous administration. Expand
Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases.
Bone metastases contribute to morbidity in patients with common cancers, and conventional therapy provides only palliation and can induce systemic side effects. The development of nanostructuredExpand
Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles.
TLDR
From a toxicological point of view, the nanocarriers produced using Kolliphor(®) P188 were the most valuable, showing no irritant effect on the ocular surface up to the highest tested surfactant concentration (0.4%, w/v). Expand
Biomaterials Applications for Nanomedicine
Paclitaxel loading in PLGA nanospheres affected the in vitro drug cell accumulation and antiproliferative activity
TLDR
The findings suggest that the greater biological effect of PTX-NS could be due to higher uptake of the drug inside the cells as shown by intracellular NS uptake and cell accumulation studies. Expand
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