variolin B
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin…
Chapter 1: Introduction Pictet-Spengler reaction has been extensively studied in the area of synthesis of different biologically…
Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin…
The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been…
The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from…
Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based…
A total synthesis of the marine alkaloid variolin B has been completed in 13 steps in an overall yield of 6.5% from 3-formyl-4…