variolin B

Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin… Expand

Chapter 1: Introduction Pictet-Spengler reaction has been extensively studied in the area of synthesis of different biologically… Expand

The authors acknowledge financial support from the Spanish Ministerio de Educacion y Ciencia (project CTQ2005/011060/BQU… Expand

Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin… Expand

The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been… Expand

Variolin B (VAR-B) is a natural product isolated from the sponge Kirkpatrickia variolosa, found in Antarctica. VAR-B has been… Expand

The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from… Expand

Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based… Expand

A total synthesis of the marine alkaloid variolin B has been completed in 13 steps in an overall yield of 6.5% from 3-formyl-4… Expand