Lamellarin D: a novel potent inhibitor of topoisomerase I.
- M. Facompré, C. Tardy, C. Bailly
- Biology, ChemistryCancer Research
- 1 November 2003
We report the identification and characterization of a novel potent inhibitor of DNA topoisomerase I: lamellarin D (LAM-D), initially isolated from a marine mollusk, Lamellaria sp., and subsequently…
Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B.
- C. Cuevas, M. Pérez, I. Manzanares
- Chemistry, BiologyOrganic Letters
- 19 July 2000
An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).
In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells.
- H. Depenbrock, R. Peter, G. Faircloth, I. Manzanares, J. Jimeno, A. Hanauske
- Biology, MedicineBritish Journal of Cancer
- 1 September 1998
Under continuous exposure, active concentrations of aplidine induced mild bone marrow toxicity, indicating that a therapeutic window at marginally myelotoxic concentrations might exist.
DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.
- M. David-Cordonnier, C. Gajate, F. Mollinedo
- Biology, ChemistryChemistry and Biology
- 1 November 2005
Stereochemistry of kahalalide F.
- I. Bonnard, I. Manzanares, K. Rinehart
- ChemistryJournal of Natural Products
- 4 November 2003
The stereochemistry of the amino acids in the marine-derived cyclic depsipeptide kahalalide F has been defined by a series of degradation reactions, yielding smaller fragments of the marine natural product.
A 3.(ET743)-DNA complex that both resembles an RNA-DNA hybrid and mimicks zinc finger-induced DNA structural distortions.
- E. Marco, R. García-Nieto, J. Mendieta, I. Manzanares, C. Cuevas, F. Gago
- Chemistry, BiologyJournal of Medicinal Chemistry
- 19 January 2002
It is shown that head-to-tail binding of three ET743 molecules to three adjacent optimal binding sites stabilizes a DNA structure whose conformation is intermediate between A- and B-form DNA.
Ecteinascidins: Putative Biosynthetic Precursors and Absolute Stereochemistry.
- R. Sakai, E. Jares-Erijman, I. Manzanares, M. Elipe, K. Rinehart
- Chemistry
- 14 January 1997
Synthesis of natural ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from cyanosafracin B.
- R. Menchaca, Valentín Martínez, C. Cuevas
- ChemistryJournal of Organic Chemistry
- 21 October 2003
The semisynthetic process initially described for the synthesis of 1 (ET-743) has been extended to the preparation of other natural ecteinascidins by procedures that can be easily scaled up.
Total synthesis and biological evaluation of tamandarin B analogues.
- J. Adrio, C. Cuevas, I. Manzanares, M. Joullié
- ChemistryJournal of Organic Chemistry
- 1 July 2007
The optimization of the previously reported synthetic route to tamandarins by changing the macrolactamization site from Nst1 and Thr6 to Pro4 and N,O-Me2Tyr5 residues led to a significant improvement in the reaction yield.
SYNTHESIS, STRUCTURE, AND ANTIMALARIAL ACTIVITY OF SOME ENANTIOMERICALLY PURE, CIS-FUSED CYCLOPENTENO-1,2,4-TRIOXANES
- C. W. Jefford, S. Kohmoto, W. Peters
- Chemistry
- 10 May 1995
Two pairs of enantiomerically pure cis-fused cyclopenteno-1,2,4-trioxanes (7, ent-7 and 8, ent-8) are prepared (Schemes 1-3). Their identities are established by dye-sensitized photo-oxygenation of…
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