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varenicline

Known as: 6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)benzazepine, 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate, Varenicline [Chemical/Ingredient] 
A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Alcohol and tobacco dependence are highly comorbid disorders, with preclinical evidence suggesting a role for… Expand
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Highly Cited
2008
Highly Cited
2008
Background: Varenicline, a new treatment for smoking cessation, has demonstrated significantly greater efficacy over placebo and… Expand
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Highly Cited
2007
Highly Cited
2007
Alcohol dependence is a disease that impacts millions of individuals worldwide. There has been some progress with pharmacotherapy… Expand
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Highly Cited
2006
Highly Cited
2006
ContextVarenicline, a partial agonist at the α4β2 nicotinic acetylcholine receptor, has the potential to aid smoking cessation by… Expand
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Highly Cited
2006
Highly Cited
2006
ContextThe α4β2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and maintaining… Expand
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Highly Cited
2006
Highly Cited
2006
CONTEXT The majority of cigarette smokers who achieve abstinence relapse within the first year and require many attempts before… Expand
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Highly Cited
2006
Highly Cited
2006
CONTEXT The alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and… Expand
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Highly Cited
2005
Highly Cited
2005
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3… Expand
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Highly Cited
2005
Highly Cited
2005
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3… Expand
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Highly Cited
2003
Highly Cited
2003
Evidence for benefit from nicotine replacement therapy in hospital patients is inconclusive, although the results of a trial… Expand
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