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valrubicin

Known as: 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate, N-Trifluoroacetyladriamycin-14-valerate, (8S, 10S)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-?-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione 8²-valerate 
A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (2)

AD 32Valtaxin

Broader (3)

Antineoplastic AgentsDoxorubicinTopoisomerase II Inhibitors
Bladder NeoplasmDrug AllergyNCIt Antineoplastic Agent TerminologyUrinary tract infection

Papers overview

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2009
2009
Plurithérapie comprenant de la valrubicine et du chlorure de trospium contre le cancer de la vessie
La presente invention concerne de nouveaux procedes utiles pour le traitement d’un patient souffrant d’un cancer de la vessie tel… 
2006
2006
Protein-associated DMA Breaks and DNA-Protein Cross-Links Caused by DMA Nonbinding Derivatives of Adriamycin in L 1210 Cells 1
The effects of Adriamycin derivatives on L1210 mouse leu kemia cells were studied with the DMA alkaline elution assay. The… 
Review
2001
Review
2001
Recent clinical trials in superficial bladder cancer
The present review addresses literature regarding the management of superficial bladder cancer published since March 2000. There… 
Review
1985
Review
1985
[Recent pharmacotoxicologic and clinical findings on adriamycin].
Anthracycline derivative adriamycin (ADR) is one of the most important anticancer drugs with major clinical application in… 
1982
1982
The effect of anoxia on anthracycline-induced DNA damage in the RPMI-6410 human lymphoblastoid cell line.
The alkaline elution procedure developed by Kohn and co-workers was used with the RPMI-6410 cultured human lymphoblastoid cell… 
1982
1982
Adriamycin analogues. Preparation of 9,10-anhydrodaunorubicin, 9,10-anhydroadriamycin, and some related compounds.
The title compounds, as well as 9,10-anhydro-N-(trifluoroacetyl)adriamycin 14-valerate (9,10-anhydro-AD 32), were prepared… 
1980
1980
N-trifluoroacetyladriamycin-14-valerate and adriamycin induced DNA damage in the RPMI-6410 human lymphoblastoid cell line.
The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410… 
1980
1980
Ultrastructural study of the cardiotoxicity and light-microscopic findings of the skin after treatment of golden hamsters with seven different anthracyclines.
Golden hamsters were administered seven anthracyclines: adriamycin (ADM), detorubicin (DTR), daunorubicin (DNR), 4'-epi… 
1980
1980
Possible relevance of N-trifluoroacetyladriamycin (AD 41) in the antitumoral activity of N-trifluoroacetyladriamycin-14-valerate (AD 32) in tumor-bearing mice. I. Pharmacokinetic evidence.
N-Trifluoroacetyladriamycin-14-valerate (AD 32) is an analog of doxorubicin whose chemico-physical characteristics are nontypical… 
1979
1979
Effects of N-trifluoroacetyladriamycin-14-valerate and related agents on DNA strand damage and thymidine incorporation in CCRF-CEM cells.
N-Trifluoroacetyladriamycin-14-valerate (AD32) and N-trifluoroacetyladriamycin (AD41) have been compared with Adriamycin and…