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valrubicin

Known as: 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate, N-Trifluoroacetyladriamycin-14-valerate, (8S, 10S)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-?-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione 8²-valerate 
A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from… Expand
National Institutes of Health

Papers overview

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2012
2012
Among numerous drug-delivery approaches, reconstituted high-density lipoprotein (rHDL) nanocarriers have proven particularly… Expand
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2001
2001
Objectives: To assess the effect and tolerance of a 6–week course of intravesical valrubicin on a tumour intentionally left in… Expand
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Highly Cited
2000
Highly Cited
2000
PURPOSE We assess the efficacy and safety of intravesical valrubicin for the treatment of carcinoma in situ in patients with… Expand
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Highly Cited
2000
Highly Cited
2000
Purpose: We assess the efficacy and safety of intravesical valrubicin for the treatment of carcinoma in situ in patients with… Expand
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1986
1986
Previous studies have demonstrated that human leukemic cells and certain cancer cells in culture have a higher uptake of plasma… Expand
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1984
1984
Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by… Expand
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1980
1980
We have used a laser flow cytometer to excite and quantitate the intracellular fluorescence of cells exposed in vitro and in vivo… Expand
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1979
1979
N-Trifluoroacetyladriamycin-14-valerate (AD-32) is superior to Adriamycin in murine L1210 and P388 leukemias and in a number of… Expand
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1978
1978
Adriamycin (ADR) and N-trifluoroacetyladriamycin-14-valerate, respectively, inhibit and enhance the nuclear fluorescence of cells… Expand
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1976
1976
Adriamycin-specific fluorescence appears slowly in living cells and is localized in nuclei and chromosomes. N… Expand
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