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urate hydroperoxide

 
National Institutes of Health

Related topics

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3 relations

Broader (2)

PeroxidesUric Acid
analogs & derivatives

Papers overview

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2019
2019
Urate hydroperoxide oxidizes endothelial cell surface protein disulfide isomerase-A1 and impairs adherence.
BACKGROUND Extracellular surface protein disulfide isomerase-A1 (PDI) is involved in platelet aggregation, thrombus formation and… Expand
2018
2018
Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation
Urate is often viewed as an antioxidant. Here, we present an alternative perspective by showing that, when oxidized, urate… Expand
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2018
2018
Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells
Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase… Expand
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2018
2018
Identification of urate hydroperoxide in neutrophils: A novel pro‐oxidant generated in inflammatory conditions
Abstract Uric acid is the final product of purine metabolism in humans and is considered to be quantitatively the main… Expand
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2017
2017
Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2
Urate hydroperoxide is a product of the oxidation of uric acid by inflammatory heme peroxidases. The formation of urate… Expand
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2015
2015
Chemical Characterization of Urate Hydroperoxide, A Pro-oxidant Intermediate Generated by Urate Oxidation in Inflammatory and Photoinduced Processes.
Urate hydroperoxide is a strong oxidant generated by the combination of urate free radical and superoxide. The formation of urate… Expand
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2015
2015
Inactivation of a Thiol-Dependent Enzyme by Urate Hydroperoxide
There are links between high serum urate (hyperuricemia) and many inflammatory diseases, yet the mechanism is obscure. Urate, the… Expand
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2010
2010
Characterization of peroxides formed by riboflavin and light exposure of milk. Detection of urate hydroperoxide as a novel oxidation product.
Characterization of peroxides by size exclusion chromatography (SEC) of milk following exposure to riboflavin and light showed… Expand
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Highly Cited
1998
Highly Cited
1998
Spectroscopic characterization of intermediates in the urate oxidase reaction.
The oxidation of urate catalyzed by soybean urate oxidase was studied under single-turnover conditions using stopped-flow… Expand
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