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Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2
TLDR
Kinetic and simulation data suggest that the oxidation of Prx2 by urate hydroperoxide occurs by a three-step mechanism, where the peroxide reversibly associates with the enzyme; then it oxidizes the peroxidatic cysteine, and finally, the rate-limiting disulfide bond is formed. Expand
Chemical Characterization of Urate Hydroperoxide, A Pro-oxidant Intermediate Generated by Urate Oxidation in Inflammatory and Photoinduced Processes.
TLDR
The oxidation of sulfur-containing biomolecules by urate hydroperoxide is likely to be a mechanism by which the pro-oxidant and damaging effects of urate are mediated in inflammatory and photo-oxidsizing processes. Expand
Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells
TLDR
The results demonstrated that HOCl is, indeed, the main relevant oxidant against bacteria and deviation of myeloperoxidase activity to produce other oxidants hampers dHL-60 killing activity. Expand
Identification of urate hydroperoxide in neutrophils: A novel pro‐oxidant generated in inflammatory conditions
TLDR
The present results support the formation of urate hydroperoxide, a novel oxidant in neutrophils oxidative burst, a strong oxidant and alters the redox balance toward a pro‐oxidative environment. Expand
Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide.
TLDR
It is indicated that the central target of Hb40-61a in Candida cells is the plasma membrane and that this synthetic hemocidin should be considered as a potential candidacidal for topic uses. Expand
Pro-Oxidant Effect of Uric Acid Metabolites in Inflammatory Cells
Uric acid is the final product of purine metabolism in humans and accumulates in plasma in the order of hundred micromolar. The one electron oxidation of uric acid by peroxidases generates urate freeExpand
Micellar effects and analytical applications of nitro substitution in 4-Nitro-N-alkyl-1,8-naphthalimide by cysteine derivatives
TLDR
4-Nitro-N-alkyl-1,8-naphthalimides can be used to evidence SH groups in peptides, proteins and living cells and can be developed at pHs between 6.5 and 7.5 thereby diminishing the rate of spontaneous oxidation of the thiols. Expand
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