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tyrphostin AG825

Known as: AG 825, AG825, Tyrphostin AG 825 
A member of the tyrphostin family of tyrosine kinase inhibitors, which selectively inhibits HER2. (NCI)
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

BenzothiazolesBenzylidene CompoundsNitrilesTyrphostins
Receptor Tyrosine Kinase Inhibition

Papers overview

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2015
2015
Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1)
Background: Neuregulin (NRG)-1-human epidermal receptor (HER)-2 signaling pathway is a key regulator of IL-1β-mediated pulmonary… 
2010
2010
Transactivation of ErbB-2 induced by tumor necrosis factor α promotes NF-κB activation and breast cancer cell proliferation
Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine which, acting locally, induces tumor growth. Accumulating evidence… 
2008
2008
Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu.
Jab1 is a coactivator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome. This protein is a potential… 
2008
2008
Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu
Jab1 is a coactivator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome. This protein is a potential… 
2008
2008
Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling.
Although the interaction between gp130 and the ErbB family has frequently been shown in cancer cells, the mechanism of this… 
2007
2007
The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway.
To determine whether the epidermal growth factor receptor 2 (ErbB2) and Akt1 can alter the in vivo growth of MCF-7 cells… 
2007
2007
HER-2/neu raises SHP-2, stops IFN-gamma anti-proliferation in bladder cancer.
2006
2006
Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder
Urinary bladder outlet obstruction results in sustained stretch of the detrusor muscle and can lead to pathological smooth muscle… 
2004
2004
Role of the aging vasculature and Erb B‐2 signaling in epidermal growth factor‐dependent intravasion of breast carcinoma cells
The risks for developing breast carcinoma and dying from the disease increase with age. Mortality from breast carcinoma usually… 
2003
2003
Tyrphostins and retinoids cooperate during inhibition of in vitro growth of ovarian cancer cells.
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