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tyrphostin AG825

Known as: AG 825, AG825, Tyrphostin AG 825 
A member of the tyrphostin family of tyrosine kinase inhibitors, which selectively inhibits HER2. (NCI)
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

BenzothiazolesBenzylidene CompoundsNitrilesTyrphostins
Receptor Tyrosine Kinase Inhibition

Papers overview

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2010
2010
Transactivation of ErbB-2 induced by tumor necrosis factor α promotes NF-κB activation and breast cancer cell proliferation
Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine which, acting locally, induces tumor growth. Accumulating evidence… 
2008
2008
Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu.
Jab1 is a coactivator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome. This protein is a potential… 
2008
2008
Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu
Jab1 is a coactivator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome. This protein is a potential… 
2007
2007
Apoptosis Induced by Depsipeptide FK228 Coincides with Inhibition of Survival Signaling in Lung Cancer Cells
Background:Whereas histone deacetylase inhibitors are known to modulate chromatin structure, the precise mechanisms by which… 
2007
2007
The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway.
To determine whether the epidermal growth factor receptor 2 (ErbB2) and Akt1 can alter the in vivo growth of MCF-7 cells… 
2006
2006
Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder
Urinary bladder outlet obstruction results in sustained stretch of the detrusor muscle and can lead to pathological smooth muscle… 
2005
2005
Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells
BackgroundPancreatic adenocarcinoma is a highly invasive neoplasm. Epidermal growth factor (EGF) and its receptor are over… 
Highly Cited
2003
Highly Cited
2003
ErbB-2 signaling is involved in regulating PSA secretion in androgen-independent human prostate cancer LNCaP C-81 cells
The expression and secretion of prostate-specific antigen (PSA) are regulated by androgens in normal prostate secretory… 
2003
2003
Estrogen-independent activation of erbBs signaling and estrogen receptor α in the mouse vagina exposed neonatally to diethylstilbestrol
Growth factors and estrogen receptor (ER) signaling cooperate to play essential roles in cell proliferation, differentiation and… 
Highly Cited
2001
Highly Cited
2001
Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.
We have recently reported that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibits epidermal growth factor (EGF) withdrawal… 
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