tumor suppressor activity

Known as: tumor suppressor 
OBSOLETE (was not defined before being made obsolete). [GOC:go_curators]
National Institutes of Health

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Cell Cycle ControlTumor Suppressor Genes

Papers overview

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Highly Cited
2012
Highly Cited
2012
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the… (More)
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Highly Cited
2010
Highly Cited
2010
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.
The roles of inflammatory cytokines and the immune response in cancer remain paradoxical. In the case of tumor necrosis factor… (More)
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Highly Cited
2005
Highly Cited
2005
ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor
Although the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF… (More)
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Highly Cited
2005
Highly Cited
2005
Wnt-5a has tumor suppressor activity in thyroid carcinoma
Stabilization of β-catenin by inhibition of its phosphorylation is characteristic of an activation of the canonical Wnt/β-catenin… (More)
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Highly Cited
2005
Highly Cited
2005
Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats
Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and… (More)
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Highly Cited
2005
Highly Cited
2005
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
Hypermethylated in cancer 1 (HIC1) is an epigenetically regulated transcriptional repressor that functionally cooperates with p53… (More)
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Highly Cited
2003
Highly Cited
2003
Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase
Telomerase expression is repressed in most somatic cells but is observed in stem cells and a high percentage of human cancers and… (More)
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Highly Cited
2002
Highly Cited
2002
Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
Shallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit localized binding of PH domains… (More)
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Highly Cited
1999
Highly Cited
1999
Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a… (More)
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Highly Cited
1998
Highly Cited
1998
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN… (More)
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