tumor suppressor activity

Known as: tumor suppressor 
OBSOLETE (was not defined before being made obsolete). [GOC:go_curators]
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the… (More)
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Highly Cited
2010
Highly Cited
2010
The roles of inflammatory cytokines and the immune response in cancer remain paradoxical. In the case of tumor necrosis factor… (More)
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Highly Cited
2005
Highly Cited
2005
Although the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF… (More)
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Highly Cited
2005
Highly Cited
2005
Stabilization of β-catenin by inhibition of its phosphorylation is characteristic of an activation of the canonical Wnt/β-catenin… (More)
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Highly Cited
2005
Highly Cited
2005
Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and… (More)
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Highly Cited
2005
Highly Cited
2005
Hypermethylated in cancer 1 (HIC1) is an epigenetically regulated transcriptional repressor that functionally cooperates with p53… (More)
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Highly Cited
2003
Highly Cited
2003
Telomerase expression is repressed in most somatic cells but is observed in stem cells and a high percentage of human cancers and… (More)
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Highly Cited
2002
Highly Cited
2002
Shallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit localized binding of PH domains… (More)
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Highly Cited
1999
Highly Cited
1999
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a… (More)
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Highly Cited
1998
Highly Cited
1998
PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN… (More)
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