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tumor suppressor activity

Known as: tumor suppressor 
OBSOLETE (was not defined before being made obsolete). [GOC:go_curators]
National Institutes of Health

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2 relations
Cell Cycle ControlTumor Suppressor Genes

Papers overview

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Highly Cited
2014
Highly Cited
2014
MicroRNA-10a Is Down-Regulated by DNA Methylation and Functions as a Tumor Suppressor in Gastric Cancer Cells
Background MicroRNAs act as posttranscriptional regulators of gene expression in many biological processes. Their deregulations… 
2013
2013
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.
Checkpoint kinase Chk1 is constitutively active in many cancer cell types and new generation Chk1 inhibitors show marked… 
2013
2013
Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis
Particularly interesting new cysteine-histidine-rich protein (PINCH) protein is part of the ternary complex known as the IPP… 
Highly Cited
2012
Highly Cited
2012
Molecular and Cellular Pathobiology The SUMOE 3-ligase PIAS 1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad… 
2010
2010
EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity
The expression of Ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) and the intragenic mutation of the ebp50 gene have been… 
Highly Cited
2005
Highly Cited
2005
RUNX3, A Novel Tumor Suppressor, Is Frequently Inactivated in Gastric Cancer by Protein Mislocalization
Loss of RUNX3 expression is suggested to be causally related to gastric cancer as 45% to 60% of gastric cancers do not express… 
Highly Cited
2003
Highly Cited
2003
The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.
The tumor suppressor gene in lung cancer (TSLC1) encodes a membrane glycoprotein containing extensive homology in the… 
2003
2003
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathways and thereby affect… 
2001
2001
Disabled-2 Exerts Its Tumor Suppressor Activity by Uncoupling c-Fos Expression and MAP Kinase Activation*
Disabled-2 (Dab2) is a putative tumor suppressor in breast and ovarian cancers. Its expression is lost in a majority of tumors… 
Highly Cited
2000
Highly Cited
2000
The von Hippel-Lindau tumor suppressor targets to mitochondria.
Subcellular localization of von Hippel-Lindau (VHL) tumor suppressor may clarify its role in tumorigenesis. In rat kidney, we… 
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