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tumor necrosis factor-alpha, CNGRC fusion protein, human

Known as: CNGRC peptide-TNF alpha conjugate, NGR-hTNF, NGR-TNF, human 
A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide… 
National Institutes of Health

Related topics

Related topics

3 relations
NCIt Antineoplastic Agent Terminology

Broader (2)

Recombinant Fusion ProteinsTumor Necrosis Factor-alpha

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The tumor vessel targeting agent NGR-TNF controls the different stages of the tumorigenic process in transgenic mice by distinct mechanisms
NGR-TNF is a vascular targeting agent in advanced clinical development, coupling tumor necrosis factor-α (TNF) with the CNGRCG… 
2013
2013
Single-walled carbon nanotubes mediated targeted tamoxifen delivery system using aspargine-glycine-arginine peptide
Abstract An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a… 
2013
2013
Randomized phase II trial of NGR-hTNF in combination with standard chemotherapy in previously untreated non-small cell lung cancer (NSCLC).
8035 Background: NGR-hTNF, a selective antivascular agent, induces at low dose an initial vascular normalization that greatly… 
Highly Cited
2011
Highly Cited
2011
Phase I Study of NGR-hTNF, a Selective Vascular Targeting Agent, in Combination with Cisplatin in Refractory Solid Tumors
Purpose: NGR-hTNF exploits the tumor-homing peptide asparagine-glycine-arginine (NGR) for selectively targeting TNF-α to an… 
2009
2009
[Relationship of serum Chemerin to obesity and type 2 diabetes mellitus].
OBJECTIVE To detect the serum Chemerin levels in patients with obesity and newly diagnosed type 2 diabetes mellitus (T2DM) and… 
2008
2008
Preclinical safety evaluation of IFNalpha2a-NGR.
2007
2007
Liminality and loss: The material culture of St Serf ‘s priory, Loch Leven, Kinross-Shire, Scotland
St Serf 's Priory also known as the Priory of Lochleven, survives as a ruin on the largest island in Lochleven, St Serf 's Island… 
2004
2004
Crucial role for interferon gamma in the synergism between tumor vasculature-targeted tumor necrosis factor alpha (NGR-TNF) and doxorubicin.
NGR-TNF is a derivative of TNF-alpha, consisting of TNF fused to CNGRCG, a tumor vasculature-targeting peptide. Previous studies… 
2002
2002
Bioavailability of recombinant tumor necrosis factor determines its lethality in mice
In mice, tumor necrosis factor (TNF) displays a selective species specificity. In contrast to murine TNF (mTNF), human TNF (hTNF… 
Review
1994
Review
1994
Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity.
The rat/mouse T-cell hybridoma PC60 was transfected either with hTNF-R55 cDNA, hTNF-R75 cDNA, or both. Receptor-specific… 
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