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Extensive translation of circular RNAs driven by N6-methyladenosine
This study reports that N6-methyladenosine (m6A), the most abundant base modification of RNA, promotes efficient initiation of protein translation from circRNAs in human cells and suggests a role of circRNA-derived proteins in cellular responses to environmental stress. Expand
[Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or
Intratumoral H101 injection showed a distinct efficacy in patients with squamous cell cancer of head and neck or esophagus, and was relatively safe. Expand
Observations of narrow bipolar events reveal how lightning is initiated in thunderstorms
Observations of a relatively unknown type of discharge, called fast positive breakdown, that is the cause of high-power discharges known as narrow bipolar events and is the initiating event of numerous lightning discharges are reported. Expand
FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non–Small Cell Lung Cancer
FGFR is a druggable target and patients with FGFR fusions may benefit from FGFR-targeted therapy, which needs further clinical investigation. Expand
Precise Diagnosis of Intraoperative Frozen Section Is an Effective Method to Guide Resection Strategy for Peripheral Small-Sized Lung Adenocarcinoma.
  • Shilei Liu, Rui Wang, +7 authors Yihua Sun
  • Medicine
  • Journal of clinical oncology : official journal…
  • 19 September 2016
Precise diagnosis by intraoperative FS is an effective method to guide resection strategy for peripheral small-sized lung adenocarcinoma and frozen pathology has a high concordance rate with FP. Expand
Lung Adenocarcinomas with HER2-Activating Mutations Are Associated with Distinct Clinical Features and HER2/EGFR Copy Number Gains
As all of the samples with HER2 mutation showed either HER2 or EGFR CNGs, these patients could potentially benefit from novel EGFR/HER2 dual or pan-erythroblastic leukemia viral oncogene homolog tyrosine kinase inhibitors. Expand
Protein kinase a modulates Cdc25B activity during meiotic resumption of mouse oocytes
Data indicate that Cdc25B‐Serine321 is the potential PKA target and CDC25B subcellular localization determines its function during the process of maintaining GV arrest in mouse oocytes. Expand
walk2friends: Inferring Social Links from Mobility Profiles
A novel social relation inference attack that relies on an advanced feature learning technique to automatically summarize users' mobility features, able to predict any two individuals' social relation, and it does not require the adversary to have any prior knowledge on existing social relations. Expand
Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations.
NSDD patients have both structural and functional alterations of subbasal corneal nerves and these changes are related to the severity of dry eye. Expand
Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways
It was found that, during the process of IDD, age-related damages together with degenerative external stimuli activated both p53-p21-Rb and p16-RB pathways to induce disc cell senescence, and disc cellsenescence was regulated by multiple signaling pathways, suggesting the complex regulating network of disc cell Senescence. Expand