tryptophan biosynthetic process

Known as: tryptophan anabolism, aromatic amino acid family biosynthetic process, anthranilate pathway, tryptophan formation 
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid… (More)
National Institutes of Health

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tryptophan synthase activity

Papers overview

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Highly Cited
2013
Highly Cited
2013
Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing
Bacteria that cause disease rely on their ability to counteract and overcome host defenses. Here, we present a genome-scale study… (More)
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Highly Cited
2010
Highly Cited
2010
Glucosinolate breakdown in Arabidopsis: mechanism, regulation and biological significance.
Glucosinolates are a group of thioglucosides in plants of the Brassicales order. Together with their hydrolytic enzymes, the… (More)
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Highly Cited
2003
Highly Cited
2003
Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.
We previously reported that laboratory reference strains of Chlamydia trachomatis differing in infection organotropism correlated… (More)
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Review
1999
Review
1999
Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering.
Rational metabolic engineering requires powerful theoretical methods such as pathway analysis, in which the topology of metabolic… (More)
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Highly Cited
1999
Highly Cited
1999
Comparative genomes of Chlamydia pneumoniae and C. trachomatis
Chlamydia are obligate intracellular eubacteria that are phylogenetically separated from other bacterial divisions. C… (More)
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Highly Cited
1996
Highly Cited
1996
The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan.
The first step of tryptophan biosynthesis is catalyzed by anthranilate synthase (AS), which is normally subject to feedback… (More)
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Highly Cited
1993
Highly Cited
1993
Suppressors of trp1 fluorescence identify a new arabidopsis gene, TRP4, encoding the anthranilate synthase beta subunit.
Suppressors of the blue fluorescence phenotype of the Arabidopsis trp1-100 mutant can be used to identify mutations in genes… (More)
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1992
1992
A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast.
Decreases in enzyme activity often have little effect on the flux carried by the pathway. Similarly, up-modulation of single… (More)
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Highly Cited
1990
Highly Cited
1990
Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications.
Two anthranilate synthase gene pairs have been identified in Pseudomonas aeruginosa. They were cloned, sequenced, inactivated in… (More)
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Highly Cited
1988
Highly Cited
1988
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.
The three-dimensional structure of the alpha 2 beta 2 complex of tryptophan synthase from Salmonella typhimurium has been… (More)
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