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hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis.
Except for a small fraction of persisters, 10(-6) to 10(-5), Escherichia coli K-12 is killed by prolonged inhibition of murein synthesis. The progeny of persisters are neither more resistant toExpand
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Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.
The hip locus of Escherichia coli affects the frequency of persistence to the lethal consequences of selective inhibition of either DNA or peptidoglycan synthesis. Regulation of the hip operon, whichExpand
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Conditional impairment of cell division and altered lethality in hipA mutants of Escherichia coli K-12.
Mutations in hipA, a gene of Escherichia coli K-12, greatly reduce the lethality of selective inhibition of peptidoglycan synthesis. These mutations have also been found to reduce the lethality thatExpand
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Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.
High-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis, the Hip phenotype, results from mutations at the hip locus of Escherichia coli K-12. TheExpand
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Molecular cloning and expression of hipA, a gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis.
The hipA gene at 33.8 min on the Escherichia coli chromosome controls the frequency of persistence upon inhibition of murein synthesis; for strains bearing hipA+ the frequency is 10(-6), and forExpand
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INHIBITORY OXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID. MECHANISM OF ACTION AND ROUTE OF DETOXIFICATION.
The use of Escherichia coli as a model organism for studies on the biochemistry of the action of indole-3-acetic acid has revealed that two products of the photooxidation of this plant hormone,Expand
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Inhibitory oxidation products of indole-3-acetic Acid: 3-hydroxymethyloxindole and 3-methyleneoxindole as plant metabolites.
Extracts of pea seedlings (Pisum sativum, variety Alaska) oxidize indole-3-acetic acid to a bacteriostatic compound which has been identified as 3-hydroxymethyloxindole. At physiological pH thisExpand
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Inhibitory Oxidation Products of Indole-3-Acetic Acid: Enzymic Formation and Detoxification by Pea Seedlings
Extracts of etiolated pea seedlings oxidize indole-3-acetic acid, a plant auxin, to 3-hydroxymethyloxindole. At physiological pH this compound is dehydrated to 3-methyleneoxindole, a highly reactiveExpand
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Mutations in multicopy Tn10 tet plasmids that confer resistance to inhibitory effects of inducers of tet gene expression.
Escherichia coli K-12 strains that carry the Tn10 tetracycline resistance determinant (tet) on multicopy plasmids are hypersensitive to 5a,6-anhydrotetracycline and heated chlortetracycline, twoExpand
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