trypanothione

Known as: N(1),N(8)-bis(gamma-Glu-hemi-Cys-Gly)sperimidine, N(1),N(8)-bis(gamma-glutamyl-hemicystinyl-glycyl)spermidine 
 
National Institutes of Health

Papers overview

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2010
2010
As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione… (More)
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2005
2005
Trypanothione plays a crucial role in regulation of intracellular thiol redox balance and in defence against chemical and oxidant… (More)
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2004
2004
The glyoxalase system is a ubiquitous pathway catalyzing the glutathione-dependent detoxication of ketoaldehydes such as… (More)
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Highly Cited
2001
Highly Cited
2001
The relative amounts of ovothiol A (N(1)-methyl-4-mercaptohistidine) and trypanothione [N(1),N(8)-bis(glutathionyl)spermidine… (More)
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Highly Cited
2000
Highly Cited
2000
The American trypanosome Trypanosoma cruzi is exposed to toxic oxygen metabolites that are generated by drug metabolism and… (More)
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Highly Cited
1997
Highly Cited
1997
Parasitic trypanosomatids comprise causative agents of debilitating or life-threatening tropical diseases. The limited capacity… (More)
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1997
1997
The mechanism of resistance to the metal arsenite has been studied and compared in L. mexicana, L. tropica, and L. tarentolae… (More)
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Highly Cited
1996
Highly Cited
1996
Leishmania resistant to arsenicals and antimonials extrude arsenite. Previous results of arsenite uptake into plasma membrane… (More)
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1988
1988
The trypanosomatid flavoprotein disulfide reductase, trypanothione reductase, is shown to catalyze one-electron reduction of… (More)
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Highly Cited
1987
Highly Cited
1987
The effect of D,L-alpha-difluoromethylornithine (DFMO) on thiol and polyamine levels in Trypanosoma brucei was investigated by… (More)
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