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trypanothione

Known as: N(1),N(8)-bis(gamma-Glu-hemi-Cys-Gly)sperimidine, N(1),N(8)-bis(gamma-glutamyl-hemicystinyl-glycyl)spermidine 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Glutathionespermidine
analogs & derivativesdethiotrypanothione

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism*
Better drugs are urgently needed for the treatment of African sleeping sickness. We tested a series of promising anticancer… 
2010
2010
Leishmania Subtilisin Is a Maturase for the Trypanothione Reductase System and Contributes to Disease Pathology*
Proteases are a ubiquitous group of enzymes that play key roles in the life cycle of parasites, in the host-parasite relationship… 
2008
2008
Antimony Resistance and Trypanothione in Experimentally Selected and Clinical Strains of Leishmania panamensis
ABSTRACT The participation of trypanothione in clinical and experimental antimony (Sb) resistance in Leishmania panamensis was… 
2005
2005
Rationally designed selective inhibitors of trypanothione reductase
Trypanothione reductase, an essential component of the anti-oxidant defences of parasitic trypanosomes and Leishmania, differs… 
Highly Cited
2004
Highly Cited
2004
Trypanothione S-Transferase Activity in a Trypanosomatid Ribosomal Elongation Factor 1B*
Trypanothione is a thiol unique to the Kinetoplastida and has been shown to be a vital component of their antioxidant defenses… 
Review
2003
Review
2003
The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors.
The presence of parasitic cysteine proteases and trypanothione reductase in the parasitic protozoa of the genus Trypanosoma and… 
Highly Cited
2001
Highly Cited
2001
Structures of Tryparedoxins Revealing Interaction with Trypanothione
Abstract Tryparedoxins (TXNs) catalyse the reduction of peroxiredoxin type peroxidases by the bisglutathionyl derivative of… 
Highly Cited
1996
Highly Cited
1996
Characterization of Trypanosoma brucei γ-Glutamylcysteine Synthetase, an Essential Enzyme in the Biosynthesis of Trypanothione (Diglutathionylspermidine)*
The parasitic protozoan Trypanosoma brucei maintains redox balance by synthesizing a conjugate of glutathione and spermidine… 
Highly Cited
1994
Highly Cited
1994
Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution.
Trypanothione reductase is an FAD-dependent disulfide oxidoreductase which catalyses the reduction of trypanothione using NADPH… 
1991
1991
Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase.
The substrate specificity of the human enzyme glutathione reductase was changed from its natural substrate glutathione to… 
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