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trypanothione

Known as: N(1),N(8)-bis(gamma-Glu-hemi-Cys-Gly)sperimidine, N(1),N(8)-bis(gamma-glutamyl-hemicystinyl-glycyl)spermidine 
 
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Protozoa of the order Kinetoplastida differ from other organisms in their ability to conjugate glutathione (l-γ-glutamyl… Expand
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Highly Cited
2002
Highly Cited
2002
Trypanosoma cruziglutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic… Expand
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Highly Cited
2001
Highly Cited
2001
The relative amounts of ovothiol A (N(1)-methyl-4-mercaptohistidine) and trypanothione [N(1),N(8)-bis(glutathionyl)spermidine… Expand
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Highly Cited
2000
Highly Cited
2000
The American trypanosome Trypanosoma cruzi is exposed to toxic oxygen metabolites that are generated by drug metabolism and… Expand
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Highly Cited
1997
Highly Cited
1997
Parasitic trypanosomatids comprise causative agents of debilitating or life-threatening tropical diseases. The limited capacity… Expand
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Highly Cited
1996
Highly Cited
1996
Leishmania resistant to arsenicals and antimonials extrude arsenite. Previous results of arsenite uptake into plasma membrane… Expand
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Highly Cited
1994
Highly Cited
1994
Trypanothione reductase is an FAD-dependent disulfide oxidoreductase which catalyses the reduction of trypanothione using NADPH… Expand
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Highly Cited
1988
Highly Cited
1988
The trypanosomatid flavoprotein disulfide reductase, trypanothione reductase, is shown to catalyze one-electron reduction of… Expand
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Highly Cited
1987
Highly Cited
1987
The effect of D,L-alpha-difluoromethylornithine (DFMO) on thiol and polyamine levels in Trypanosoma brucei was investigated by… Expand
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Highly Cited
1986
Highly Cited
1986
Trypanothione reductase from Crithidia fasciculata has been purified ca. 1400-fold to homogeneity in an overall yield of 60%. The… Expand
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