spermidine

Known as: 4-Azaoctamethylenediamine, 1,4-Diaminobutane, N-(3-Aminopropyl)-, 4-Azaoctane-1,8-Diamine 
A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values… (More)
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (40)

1-amino-8-acetamido-5-azanonane1-methylspermidine5,8-dimethylspermidine6,6-difluorospermidine
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In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Broader (2)

PolyaminesPutrescine

Papers overview

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Highly Cited
2016
Highly Cited
2016
Cardioprotection and lifespan extension by the natural polyamine spermidine
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the… (More)
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Review
2016
Review
2016
The crucial impact of lysosomes in aging and longevity
Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of cellular processes, including… (More)
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Highly Cited
2011
Highly Cited
2011
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Autophagy protects organelles, cells, and organisms against several stress conditions. Induction of autophagy by resveratrol… (More)
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Review
2011
Review
2011
Autophagy and Aging
Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and… (More)
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Highly Cited
2009
Highly Cited
2009
Induction of autophagy by spermidine promotes longevity
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful… (More)
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Review
2009
Review
2009
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence… (More)
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Highly Cited
2007
Highly Cited
2007
Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide
The polyamines spermidine and spermine have been hypothesized to possess different functions in the protection of DNA from… (More)
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Highly Cited
1999
Highly Cited
1999
Oxidative stress and some antioxidant systems in acid rain-treated bean plants Protective role of exogenous polyamines
The effect of simulated acid rain (AR) (pH 1.8) on H2O2 and malonyldialdehyde (MDA) levels and activities of peroxidase and… (More)
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Review
1993
Review
1993
Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism.
Polyamines are thought to have several vital roles in cell growth and differentiation. The highly regulated polyamine metabolic… (More)
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Review
1976
Review
1976
1,4-Diaminobutane (putrescine), spermidine, and spermine.
As is evident from the above summary of the recent literature, plus many other papers not cited here, there is an extensive… (More)
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