Compartmentalization of spermine and spermidine in the herpes simplex virion.

@article{Gibson1971CompartmentalizationOS,
  title={Compartmentalization of spermine and spermidine in the herpes simplex virion.},
  author={Wade Gibson and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1971},
  volume={68 11},
  pages={2818-21}
}
Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 +/- 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection. 

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