Compartmentalization of spermine and spermidine in the herpes simplex virion.

  title={Compartmentalization of spermine and spermidine in the herpes simplex virion.},
  author={Wade Gibson and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={68 11},
Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 +/- 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection. 

From This Paper

Figures, tables, and topics from this paper.
31 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…