tropisetron

Known as: (3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester, 1H-Indole-3-carboxylic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-, indole-3-carboxylic acid tropine ester 
An indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
OBJECTIVES Preclinical studies have suggested that the mechanism of the analgesic action of acetaminophen (INN, paracetamol) is… (More)
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Highly Cited
2005
Highly Cited
2005
Physiological deficits in inhibition of the P50 auditory evoked potential in schizophrenia have been related to diminished… (More)
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2002
2002
UNLABELLED Dexamethasone is an effective antiemetic drug, but the efficacy of small-dose dexamethasone 5 mg on the prophylaxis of… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE The use of serotonin 5-hydroxytryptamine type 3 receptor antagonists has substantially reduced, but not eliminated… (More)
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Highly Cited
2002
Highly Cited
2002
Neocortical neurons expressing the serotonin 5-HT3 receptor (5-HT3R) were characterized in rat acute slices by using patch-clamp… (More)
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Highly Cited
2001
Highly Cited
2001
Formalin injected subcutaneously into the paw is a widely used model of pain. This procedure evokes a short-lasting period of… (More)
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Highly Cited
2001
Highly Cited
2001
The 5-HT3 receptor antagonist tropisetron (ICS 205-930) was found to be a potent and selective partial agonist at alpha7… (More)
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2001
2001
A prospective, randomized, placebo-controlled, multicenter, double-blind trial in fibromyalgia patients demonstrated that peroral… (More)
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Review
2000
Review
2000
Pain, nausea and vomiting are frequently listed by patients as their most important perioperative concerns. With the change in… (More)
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1998
1998
Nausea and vomiting are common after adenotonsillectomy. Tropisetron is a new, long-acting serotonin antagonist that is an… (More)
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