J. Leander

Publications199
h-index41
Citations5,270
Highly Influential Citations155
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GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
TLDR
It is shown that GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats without exhibiting substance abuse-related, gating, and sedative side effects of ketamine.
View on Nature
SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task.
View on PubMed
m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT2C receptors but not 5-HT2A or 5-HT2B receptors
TLDR
A detailed pharmacological evaluation with selective antagonists for the 5-HT2 family of receptors supports a primary role for the 1-(m-chlorophenyl)piperazine receptor in mediating the hypolocomotion produced by m-CPP.
View on Wolters Kluwer
A kappa opioid effect: increased urination in the rat.
  • J. Leander
  • Biology, Medicine
    The Journal of pharmacology and experimental…
  • 1983
TLDR
The data suggest the hypothesis that dynorphin, a kappa agonist, acts as an endogenous ligand for an autoreceptor which inhibits the corelease of Dynorphin and antidiuretic hormone from the neurohypophysis, which produces the increased urination.
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Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
TLDR
Results seem to indicate a major role for the mu receptor in the analgesic actions of these compounds, and suggest that beta-FNA is selective for mu over kappa receptors under the conditions used in this study.
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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
TLDR
Understanding the mechanistic underpinning of GLYX-13's antidepressant action should provide both novel insights into the role of the glutamatergic system in depression and identify new targets for therapeutic development.
View on Taylor & Francis
In vitro and in vivo antagonism of AMPA receptor activation by (3s,4ar,6r,8ar)-6-[2-(1(2)h-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid
View on Elsevier
The behavioral pharmacology of NMDA receptor antagonists.
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The effect of streptozotocin-induced diabetes on cell proliferation in the rat dentate gyrus
View on Elsevier
Diuresis and suppression of vasopressin by kappa opioids: comparison with mu and delta opioids and clonidine.
TLDR
The hypothesis that kappa opioid agonists produce a diuretic effect by suppressing plasma levels of vasoppressin, and at higher doses produce a pattern of urination similar to animals lacking vasopressin, is supported.
View on PubMed
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