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GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
It is shown that GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats without exhibiting substance abuse-related, gating, and sedative side effects of ketamine.
m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT2C receptors but not 5-HT2A or 5-HT2B receptors
A detailed pharmacological evaluation with selective antagonists for the 5-HT2 family of receptors supports a primary role for the 1-(m-chlorophenyl)piperazine receptor in mediating the hypolocomotion produced by m-CPP.
A kappa opioid effect: increased urination in the rat.
  • J. Leander
  • Biology, Medicine
    The Journal of pharmacology and experimental…
  • 1983
The data suggest the hypothesis that dynorphin, a kappa agonist, acts as an endogenous ligand for an autoreceptor which inhibits the corelease of Dynorphin and antidiuretic hormone from the neurohypophysis, which produces the increased urination.
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Results seem to indicate a major role for the mu receptor in the analgesic actions of these compounds, and suggest that beta-FNA is selective for mu over kappa receptors under the conditions used in this study.
GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
Understanding the mechanistic underpinning of GLYX-13's antidepressant action should provide both novel insights into the role of the glutamatergic system in depression and identify new targets for therapeutic development.
The behavioral pharmacology of NMDA receptor antagonists.
Diuresis and suppression of vasopressin by kappa opioids: comparison with mu and delta opioids and clonidine.
The hypothesis that kappa opioid agonists produce a diuretic effect by suppressing plasma levels of vasoppressin, and at higher doses produce a pattern of urination similar to animals lacking vasopressin, is supported.