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trimelamol

Known as: N(2),N(4),N(6)-trihydroxymethyl-N(2),N(4),N(6)-trimethylmelamine, Trimethyloltrimethylmelamine, Methanol, (1,3,5-triazine-2,4,6-triyltris(methylimino))tris- 
A synthetic derivative of trimethylmelamine with antineoplastic properties. An analogue of siderophores (microbial iron chelators), trimelamol… 
National Institutes of Health

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Triazines

Papers overview

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2012
2012
Comparison of DNA Methylmelamlnes and Damage by Formaldehyde 1
The cytotoxicity and DNA damaging activity of 59-activated hexamethylmelamine (HMM) and pentamethylmelamine (PMM) were compared… 
2007
2007
Low central nervous system penetration of N 2 , N 4 , N 6 ,-trihydroxymethyl-N 2 , N 4 , N 6-trimethylmelamine ( Trimelamol ) : A cytotoxic s-triazine with reduced neurotoxicity
Trimelamol (N2,N4,N6-trihydroxymethyl-N2,N4,N6-trimethylmelamine) is an analogue of pentamethylmelamine (PMM). In early clinical… 
2004
2004
Preclinical toxicology, pharmacokinetics and formulation of N2, N4, N6-trihydroxymethyl-N2, N4, N6-trimethylmelamine (Trimelamol), a water-soluble cytotoxic s-triazine which does not require…
SummaryN2, N4, N6-Trihydroxymethyl-N2, N4, N6-trimethylmelamine (Trimelamol) is a water-soluble synthetic s-triazine which… 
2004
2004
Superior efficacy of trimelamol to hexamethylmelamine in human ovarian cancer xenografts
SummaryA series of eight human ovarian cancer lines grown in nude mice were used to compare the activity of hexamethylmelamine… 
Review
1997
Review
1997
N-(Hydroxymethyl) melamines.
1996
1996
Framework-Reactive Siderophore Analogs as Potential Cell-Selective Drugs. Design and Syntheses of Trimelamol-Based Iron Chelators.
Currently, the role of DNA-directed alkylating agents as potential anticancer/ antimicrobial drugs is of wide interest. Most of… 
1996
1996
Pre‐clinical development of the anti‐tumour agent CB 7646, BIS N‐(hydroxymethyl) trimethylmelamine, a stable analogue of trimelamol
Formulation difficulties prevented the otherwise promising clinical development of the anti‐tumour agent trimelamol (TM; tris… 
1991
1991
Studies on the stability of trimelamol, a carbinolamine-containing antitumor drug.
The stability of trimelamol (N2,N4,N6-trimethylol-N2,N4,N6-trimethylmelamine) a synthetic carbinolamine-containing antitumor drug… 
1991
1991
N2,N4,N6-tri(hydroxymethyl)-N2,N4,N6-trimethylmelamine (trimelamol) is an efficient DNA cross-linking agent in vitro.
1990
1990
Development of a parenteral formulation of trimelamol, a synthetic S-triazine carbinolamine-containing cytotoxic agent.
Trimelamol is a synthetic s-triazine carbinolamine-containing agent exhibiting poor aqueous solubility and stability… 
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