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Stereoselective total synthesis of racemic BCX-1812 (RWJ-270201) for the development of neuraminidase inhibitors as anti-influenza agents.
A convergent and versatile racemic total synthesis of the anti-influenza agent BCX-1812 (RWJ-270201) was accomplished on the basis of a sequence of stereoselective reactions due to flexibility that will eventually accommodate diversified substituents. Expand
Peptides Selected for the Protein Nanocage Pores Change the Rate of Iron Recovery from the Ferritin Mineral*
The results emphasize that small peptides can exploit the structural plasticity of protein pores to modulate function and may model regulators of ferritin demineralization rates in vivo or peptide regulators of gated pores in membranes. Expand
Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers.
Two desferrioxamine B-ciprofloxacin conjugates with 'trimethyl-lock' based linkers that are designed to release the antibiotic after esterase or phosphatase-mediated hydrolysis were synthesized displayed moderate to good antibacterial activities against selected ferrioxamines-utilizing bacteria. Expand
Syntheses and biological evaluation of ring-C modified colchicine analogs.
Ring-C modified alkaloids were synthesized from colchicine using iminonitroso Diels-Alder reactions in a highly regio- and stereoselective fashion. Several analogs exhibited cytotoxic activityExpand
Total synthesis of desferrisalmycin B.
The first total synthesis of a naturally occurring siderophore antibiotic, desferrisalmycin B, is described, and the configuration of the unknown stereocenter is assigned. The synthesis features aExpand
A New Method for the Synthesis ofN.epsilon.-Acetyl-N.epsilon.-hydroxy-L-lysine, the Iron-Binding Constituent of Several Important Siderophores
Oxidation of the e-amino group of N α -(carbobenzyloxy)-L-lysine methyl ester with dimethyldioxirane in acetone gave the acetone-derived nitrone of the desired hydroxylamine. Acidic hydrolysis,Expand