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tiplaxtinin

National Institutes of Health

Papers overview

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Review
2015
Review
2015
PAI-1, a glycoprotein from the serpin family and the main inhibitor of tPA and uPA, plays an essential role in the regulation of… Expand
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Highly Cited
2013
Highly Cited
2013
Cancers of the urinary bladder result in aggressive and highly angiogenic tumors for which standard treatments have only limited… Expand
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2012
2012
Spatial and temporal regulation of the pericellular proteolytic environment by local growth factors, such as EGF and TGF… Expand
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2008
2008
Summary.  Objective: To assess the antithrombotic and profibrinolytic effects of tiplaxtinin (PAI‐039), an orally bioavailable… Expand
2008
2008
This study aimed to evaluate a small-molecule PAI-1 inhibitor (PAI-039; tiplaxtinin) in a rodent stenosis model of venous… Expand
Highly Cited
2007
Highly Cited
2007
The inactivation of plasminogen activator inhibitor-1 (PAI-1) by the small molecule PAI-1 inhibitor PAI-039 (tiplaxtinin) has… Expand
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2006
2006
To investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on… Expand
Highly Cited
2006
Highly Cited
2006
Hepatic veno-occlusive disease (VOD) is a common complication of high-dose chemotherapy associated with bone marrow… Expand
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Highly Cited
2006
Highly Cited
2006
Summary.  Background: Plasminogen activator inhibitor‐1 (PAI‐1) is integrally involved in tumorigenesis by impacting on both… Expand
Highly Cited
2004
Highly Cited
2004
Indole oxoacetic acid derivatives were prepared and evaluated for in vitro binding to and inactivation of human plasminogen… Expand
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