AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase*
It is shown that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser428, and AMPK activity, which suggests that Sirt1 functions as a novel upstream regulator for L KB1/AMPK signaling and plays an essential role in the regulation of hepatocyte lipid metabolism.
Endothelial dysfunction in diabetes
- A. D. De Vriese, T. Verbeuren, J. van de Voorde, N. Lameire, P. Vanhoutte
- Medicine, BiologyBritish Journal of Pharmacology
- 1 July 2000
Correcting the principal mediators of hyperglycaemia‐induced endothelial dysfunction may be activation of protein kinase C, increased activity of the polyol pathway, non‐enzymatic glycation and oxidative stress, as well as administration of ACE inhibitors and folate has been shown to improve endothelium‐dependent vasodilation in diabetes.
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice
It is revealed that inactivation of hepatic AMPK is a key event in the pathogenesis of hyperlipidemia in diabetes, point to a novel mechanism of action of polyphenols to lower lipids by activating AMPK, and emphasize a new therapeutic avenue to benefit hyper Lipidemia and atherosclerosis specifically in diabetes.
Endothelium‐dependent contractions in SHR: a tale of prostanoid TP and IP receptors
- M. Félétou, T. Verbeuren, P. Vanhoutte
- Biology, MedicineBritish Journal of Pharmacology
- 1 February 2009
Because EDCFs converge to activate TP receptors, selective antagonists of this receptor, by preventing endothelium‐dependent contractions, curtail the endothelial dysfunction in diseases such as hypertension and diabetes.
In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors.
- P. Gluais, J. Paysant, C. Badier-Commander, T. Verbeuren, P. Vanhoutte, M. Félétou
- Biology, MedicineAmerican Journal of Physiology. Heart and…
- 1 November 2006
Results indicate that in the aorta of SHR and WKY, the endothelium-dependent contractions involve the release of thromboxane A(2) and prostacyclin with a most likely concomitant contribution of PGH(2).
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis.
- A. Cayatte, Y. Du, J. Oliver-Krasinski, G. Lavielle, T. Verbeuren, R. Cohen
- Biology, MedicineArteriosclerosis, Thrombosis and Vascular Biology
- 1 July 2000
Comparisons of the effects of aspirin and the TP receptor antagonist S18886 suggest that blockade of TP receptors inhibits atherosclerosis by a mechanism independent of platelet-derived TxA(2), perhaps by preventing the expression of adhesion molecules whose expression is stimulated by eicosanoids other than Tx a(2).
Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study
- C. Badier-Commander, A. Couvelard, D. Henin, T. Verbeuren, J. Michel, M. Jacob
- Biology, MedicineJournal of Pathology
- 1 March 2001
Results show that phenotypic modulation of smooth muscle cells, altered extracellular matrix metabolism, and angiogenesis are the main mechanisms contributing to the morphological and functional modifications of varicose remodelling.
Vasoreactivity of the Radial Artery Comparison With the Internal Mammary and Gastroepiploic Arteries With Implications for Coronary Artery Surgery
This increased reactivity of the radial artery explains its propensity to spasm and emphasizes the need for antispastic drugs and platelet inhibitors when the radial arteries is used for coronary artery bypass.
Increased TIMP/MMP ratio in varicose veins: a possible explanation for extracellular matrix accumulation
- C. Badier-Commander, T. Verbeuren, C. Lebard, J. Michel, M. Jacob
- BiologyJournal of Pathology
- 1 September 2000
It is demonstrated that varicose veins are characterized by a higher than normal TIMP/MMP ratio, which may facilitate extracellular matrix accumulation in the diseased venous wall.