• Publications
  • Influence
SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase*
Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase. Because we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenolsExpand
  • 646
  • 50
Endothelial dysfunction in diabetes
Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease. The endothelium controls the tone of the underlying vascular smooth muscle through the production ofExpand
  • 1,060
  • 34
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice
Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein kinaseExpand
  • 585
  • 29
  • PDF
Endothelium‐dependent contractions in SHR: a tale of prostanoid TP and IP receptors
In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to the release of endothelium‐derived contracting factors (EDCFs) that counteract the vasodilator effect ofExpand
  • 135
  • 13
In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors.
In mature spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), acetylcholine and the calcium ionophore A-23187 release endothelium-derived contracting factors (EDCFs), cyclooxygenaseExpand
  • 78
  • 12
  • PDF
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis.
Atherosclerosis involves a complex array of factors, including leukocyte adhesion and platelet vasoactive factors. Aspirin, which is used to prevent secondary complications of atherosclerosis,Expand
  • 230
  • 7
  • PDF
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.
The serotonergic receptor antagonist 3-(2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl)-2,4-[1H,3H]quinazolinedione Ketanserin (R 41 468) caused a dose-dependent inhibition on the contractile responsesExpand
  • 508
  • 4
Increased TIMP/MMP ratio in varicose veins: a possible explanation for extracellular matrix accumulation
Primary varicose veins are functionally characterized by venous back‐flow and blood stagnation in the upright position. Dilatation and tortuosity provide evidence for progressive venous wallExpand
  • 131
  • 4
S 18886, a new thromboxane (TP)-receptor antagonist is the active isomer of S 18204 in all species, except in the guinea-pig.
Thromboxane (TXA2) causes platelet aggregation, vasoconstriction and cell proliferation through the activation of specific cell membrane TP-receptors1, 2. TXA2 is implicated in thrombotic disordersExpand
  • 52
  • 4