thrombin activity

OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B. [EC:3.4.21.5]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1957-2018
010203019572017

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Highly Cited
2006
Highly Cited
2006
Complement-mediated tissue injury in humans occurs upon deposition of immune complexes, such as in autoimmune diseases and acute… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVES We investigated the relation of high ex vivo platelet reactivity, rapid fibrin generation, and high thrombin-induced… (More)
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2004
2004
In addition to its central role in hemostasis, thrombin may play a role in inflammation and remodeling. To investigate the… (More)
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2002
2002
OBJECTIVE Thrombin, a serine protease, plays an important role in thrombosis as well as other cellular and developmental… (More)
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Highly Cited
2000
Highly Cited
2000
A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Thrombolytic therapy induces a procoagulant state characterized by elevated plasma levels of fibrinopeptide A (FPA… (More)
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1995
1995
BACKGROUND The abrupt cessation of heparin and other thrombin inhibitors when used to treat acute coronary syndromes has been… (More)
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Highly Cited
1993
Highly Cited
1993
A method is described by which the time-course of thrombin generation in plasma can be obtained from a continuous optical density… (More)
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1993
1993
Assays which detect the release of platelet-specific proteins and of peptides during thrombogenesis and are considered markers of… (More)
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Highly Cited
1990
Highly Cited
1990
Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To… (More)
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