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Differential control of cellular gene expression by diffusible and non-diffusible EGF.
Cell gene expression is affected by both the kind and mode of growth factor stimulation (diffusive vs. non-diffusive) and the switching between growth stimulation and differentiation is considered to be due to the duration of the stimulus.
Enhancement of the mitogenic effect by artificial juxtacrine stimulation using immobilized EGF.
Mouse epidermal growth factor Culturing cells with PMMA-immobilized EGF represents a model system for studying "juxtacrine" stimulation of cells by membrane-bound growth factors.
Protein-free cell culture on an artificial substrate with covalently immobilized insulin.
- Y. Ito, J. Zheng, Y. Imanishi, K. Yonezawa, M. Kasuga
- Biology, MedicineProceedings of the National Academy of Sciences…
- 16 April 1996
Immobilized insulin activated the insulin receptor and downstream signaling proteins, and this activation persisted for longer periods than that obtained with free insulin, probably explaining the greater mitogenic effect of the immobilized insulin.
Photo-immobilization of epidermal growth factor enhances its mitogenic effect by artificial juxtacrine signaling.
- G. Chen, Y. Ito, Y. Imanishi
- BiologyBiochimica et Biophysica Acta
- 11 September 1997
Cell growth on immobilized cell growth factor. I. Acceleration of the growth of fibroblast cells on insulin-immobilized polymer matrix in culture medium without serum.
- S. Liu, Y. Ito, Y. Imanishi
- BiologyBiomaterials
- 1992
Micropatterned immobilization of epidermal growth factor to regulate cell function.
- Y. Ito, G. Chen, Y. Imanishi
- Biology, ChemistryBioconjugate chemistry
- 12 February 1998
The partial staining of activated proteins indicates that immobilization of EGF inhibited the free lateral diffusion and internalization of the activated EGF-EGF receptor complex, which is due to juxtacrine stimulation realized by immobilized EGF.
An insulin-releasing system that is responsive to glucose
- Yoshihiro Ito, M. Casolaro, K. Kono, Y. Imanishi
- Chemistry
- 1 November 1989
Catalytic activity and conformation of chemically modified subtilisin Carlsberg in organic media.
- O. Kwon, Y. Imanishi, Y. Ito
- ChemistryBiotechnology and bioengineering
- 1999
Subtilisin Carlsberg, an alkaline protease from Bacillus licheniformis, was modified with polyoxyethylene (PEG) or aerosol-OT (AOT), and the solubility, conformation, and catalytic activity of the…
In vitro selection of a ligase ribozyme carrying alkylamino groups in the side chains.
- N. Teramoto, Y. Imanishi, Y. Ito
- Biology, ChemistryBioconjugate chemistry
- 3 November 2000
A novel ligase ribozyme was in vitro selected from a random-sequence RNA library including N(6)-aminohexyl-modified adenine residues in place of natural adenine residues. This ribozyme mediated the…
A Molecular Photodiode System That Can Switch Photocurrent Direction
- S. Yasutomi, T. Morita, Y. Imanishi, S. Kimura
- Chemistry, PhysicsScience
- 25 June 2004
A molecular photodiode system in which the photocurrent direction can be switched by choosing the wavelength of an irradiating light is prepared, composed of two types of helical peptides that carry different chromophores and have different directions of dipole moments when they are immobilized on gold.
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