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thermozymocidin

Known as: 2-amino-2-hydroxymethyl-3,4-dihydroxy-14- oxoeicos-6-enoic acid, SPI-1 inhibitor, myriocin 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Antifungal AgentsFatty Acids, MonounsaturatedImmunosuppressive Agents

Narrower (1)

ISP-1 suppressant

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status.
2014
2014
Ceramides mediate cigarette smoke-induced metabolic disruption in mice.
Cigarette smoke exposure increases lung ceramide biosynthesis and alters metabolic function. We hypothesized that ceramides are… 
2014
2014
Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
2014
2014
Myriocin induces apoptotic lung cancer cell death via activation of DR4 pathway
It has been known that myriocin inhibits melanoma growth. However, the effects and action mechanisms of myriocin on lung cancer… 
2013
2013
Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol‐related steatohepatitis
Alcohol‐related liver disease (ALD) is mediated in part by insulin resistance. Attendant dysregulation of lipid metabolism… 
2012
2012
Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, is generated from sphingosine by sphingosine kinases and binds five… 
2007
2007
De Novo Sphingolipid Synthesis Is Essential for Viability, but Not for Transport of Glycosylphosphatidylinositol-Anchored Proteins, in African Trypanosomes
ABSTRACT De novo sphingolipid synthesis is required for the exit of glycosylphosphatidylinositol (GPI)-anchored membrane proteins… 
2004
2004
Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations.
Highly Cited
1994
Highly Cited
1994
Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin…
In order to investigate the structure-activity relationships, fourteen derivatives of myriocin ((2S,3R,4R)-(E)-2-amino-3,4… 
1994
1994
Total synthesis of a novel immunosuppressant, myriocin (thermozymocidin, ISP-I), and Z-myriocin.
Myriocin (thermozymocidin, ISP-I), which was known to exhibit several interesting biological properties such as potent… 
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