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tetrahydrobiopterin biosynthetic process

Known as: tetrahydrobiopterin formation, tetrahydrobiopterin synthesis, tetrahydrobiopterin biosynthesis 
The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.
We introduce an approach for detection of drug-protein interactions that combines a new yeast three-hybrid screening for… Expand
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Highly Cited
2011
Highly Cited
2011
Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis
Background— The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic… Expand
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Highly Cited
2009
Highly Cited
2009
Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.
Chronic administration of the most abundant dietary flavonoid quercetin exerts antihypertensive effects and improves endothelial… Expand
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Highly Cited
2008
Highly Cited
2008
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
OBJECTIVE HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for… Expand
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Highly Cited
2004
Highly Cited
2004
Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice
Objective—Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features… Expand
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Review
2004
Review
2004
Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells
Tetrahydrobiopterin (BH4) is a member of the pterin family that has a core structure of pyrazino-2,3-d-pyrimidine rings. Because… Expand
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Highly Cited
2001
Highly Cited
2001
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin*
Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion… Expand
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Highly Cited
1995
Highly Cited
1995
Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries.
BACKGROUND The L-arginine/nitric oxide pathway plays a key role in the regulation of arterial tone. Biosynthesis of nitric oxide… Expand
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Highly Cited
1994
Highly Cited
1994
Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase…
We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h… Expand
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Highly Cited
1990
Highly Cited
1990
Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase…
Interferon-gamma induces tetrahydrobiopterin biosynthesis in human cells and cell lines. Macrophages are peculiar in the… Expand
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