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tetrahydrobiopterin biosynthetic process
Known as:
tetrahydrobiopterin formation
, tetrahydrobiopterin synthesis
, tetrahydrobiopterin biosynthesis
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The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
In vivo evidence for compromised phenylalanine metabolism in vitiligo.
K. Schallreuter
,
M. Zschiesche
,
+5 authors
J. Sawatzki
Biochemical and Biophysical Research…
1998
Corpus ID: 879162
Human epidermal melanocytes and keratinocytes express mRNA for all enzymes involved in de novo synthesis/recycling of the…
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1998
1998
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
M. Ishii
,
Shunichi Shimizu
,
Kazutaka Momose
,
Toshinori Yamamoto
Acta Pharmacologica et Toxicologica
1998
Corpus ID: 22628482
The purpose of this study was to examine the effect of tetrahydrobiopterin, a co-factor of nitric oxide synthase, on H2O2-induced…
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1996
1996
Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock.
A. Bune
,
M. Brand
,
S. Heales
,
J. K. Shergill
,
Richard Cammack
,
H. Cook
Biochemical and Biophysical Research…
1996
Corpus ID: 22046164
Nitric oxide synthesis requires the cofactor tetrahydrobiopterin. We have examined the effect on nitric oxide synthesis in…
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Highly Cited
1996
Highly Cited
1996
Tetrahydrobiopterin and Biogenic Amine Metabolism in the hph‐1 Mouse
K. Hyland
,
R. S. Gunasekera
,
T. Engle
,
L. Arnold
Journal of Neurochemistry
1996
Corpus ID: 10020848
Abstract: hph‐1 mice, which have defective tetrahydrobiopterin biosynthesis due to decreased GTP cyclohydrolase I activity, have…
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1994
1994
Tetrahydrobiopterin as another EDRF in man.
A. Schaffner
,
N. Blau
,
M. Schneemann
,
J. Steurer
,
C. Edgell
,
G. Schoedon
Biochemical and Biophysical Research…
1994
Corpus ID: 44960969
Endotoxin and inflammatory cytokines downregulate expression of constitutive nitric oxide synthase (cNOS) in human vascular…
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Highly Cited
1993
Highly Cited
1993
Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat
G. Werner-Felmayer
,
H. Prast
,
E. Werner
,
A. Philippu
,
H. Wachter
FEBS Letters
1993
Corpus ID: 40469502
Highly Cited
1993
Highly Cited
1993
Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: new perspectives on endothelium-derived relaxing factor.
G. Schoedon
,
M. Schneemann
,
N. Blau
,
C. Edgell
,
A. Schaffner
Biochemical and Biophysical Research…
1993
Corpus ID: 26614985
Endothelial cells, through soluble mediators, play an important role in the regulation of the vascular tone. In the present paper…
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Highly Cited
1990
Highly Cited
1990
Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2.
I. Ziegler
,
K. Schott
,
M. Lübbert
,
F. Herrmann
,
U. Schwuléra
,
A. Bacher
Journal of Biological Chemistry
1990
Corpus ID: 45517139
1987
1987
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin.
G. K. Smith
Archives of Biochemistry and Biophysics
1987
Corpus ID: 45126718
Highly Cited
1982
Highly Cited
1982
Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain.
S. Kaufman
,
G. Kapatos
,
R. Mcinnes
,
J. Schulman
,
W. Rizzo
Pediatrics
1982
Corpus ID: 22487414
Substantial amounts of tetrahydrobiopterin and 6-methyltetrahydropterin can be detected in CSF when these pterins are given…
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