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tetrahydrobiopterin biosynthetic process

Known as: tetrahydrobiopterin formation, tetrahydrobiopterin synthesis, tetrahydrobiopterin biosynthesis 
The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2… 
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
In vivo evidence for compromised phenylalanine metabolism in vitiligo.
Human epidermal melanocytes and keratinocytes express mRNA for all enzymes involved in de novo synthesis/recycling of the… 
1998
1998
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
The purpose of this study was to examine the effect of tetrahydrobiopterin, a co-factor of nitric oxide synthase, on H2O2-induced… 
1996
1996
Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock.
Nitric oxide synthesis requires the cofactor tetrahydrobiopterin. We have examined the effect on nitric oxide synthesis in… 
Highly Cited
1996
Highly Cited
1996
Tetrahydrobiopterin and Biogenic Amine Metabolism in the hph‐1 Mouse
Abstract: hph‐1 mice, which have defective tetrahydrobiopterin biosynthesis due to decreased GTP cyclohydrolase I activity, have… 
1994
1994
Tetrahydrobiopterin as another EDRF in man.
Endotoxin and inflammatory cytokines downregulate expression of constitutive nitric oxide synthase (cNOS) in human vascular… 
Highly Cited
1993
Highly Cited
1993
Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat
Highly Cited
1993
Highly Cited
1993
Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: new perspectives on endothelium-derived relaxing factor.
Endothelial cells, through soluble mediators, play an important role in the regulation of the vascular tone. In the present paper… 
Highly Cited
1990
Highly Cited
1990
Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2.
1987
1987
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin.
Highly Cited
1982
Highly Cited
1982
Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain.
Substantial amounts of tetrahydrobiopterin and 6-methyltetrahydropterin can be detected in CSF when these pterins are given… 
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