tetrahydrobiopterin biosynthetic process

Known as: tetrahydrobiopterin formation, tetrahydrobiopterin synthesis, tetrahydrobiopterin biosynthesis 
The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
051019782018

Papers overview

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2008
2008
OBJECTIVE HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for… (More)
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Highly Cited
2007
Highly Cited
2007
An essential cofactor for the endothelial NO synthase is tetrahydrobiopterin (H4B). In the present study, we show that in human… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features… (More)
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Highly Cited
2002
Highly Cited
2002
The present study was designed to investigate the interaction between 5-methyltetrahydrofolate and tetrahydrobiopterin in… (More)
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Highly Cited
2001
Highly Cited
2001
Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion… (More)
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Highly Cited
1996
Highly Cited
1996
The cytokine-inducible isoform of nitric oxide synthase (iNOS or NOS2) plays an important role in the immune response to some… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The L-arginine/nitric oxide pathway plays a key role in the regulation of arterial tone. Biosynthesis of nitric oxide… (More)
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Highly Cited
1994
Highly Cited
1994
We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h… (More)
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Highly Cited
1993
Highly Cited
1993
Stimulation of nitric oxide (NO) synthase in endothelial cells by Ca2+ influx leads to increased intracellular levels of cGMP. NO… (More)
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1990
1990
The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with… (More)
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