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tetrahydrobiopterin biosynthetic process

Known as: tetrahydrobiopterin formation, tetrahydrobiopterin synthesis, tetrahydrobiopterin biosynthesis 
The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
We introduce an approach for detection of drug-protein interactions that combines a new yeast three-hybrid screening for… Expand
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Highly Cited
2011
Highly Cited
2011
Background— The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic… Expand
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Highly Cited
2009
Highly Cited
2009
Chronic administration of the most abundant dietary flavonoid quercetin exerts antihypertensive effects and improves endothelial… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for… Expand
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Highly Cited
2004
Highly Cited
2004
Objective—Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features… Expand
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Review
2004
Review
2004
Tetrahydrobiopterin (BH4) is a member of the pterin family that has a core structure of pyrazino-2,3-d-pyrimidine rings. Because… Expand
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Highly Cited
2001
Highly Cited
2001
Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The L-arginine/nitric oxide pathway plays a key role in the regulation of arterial tone. Biosynthesis of nitric oxide… Expand
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Highly Cited
1994
Highly Cited
1994
We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h… Expand
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Highly Cited
1990
Highly Cited
1990
Interferon-gamma induces tetrahydrobiopterin biosynthesis in human cells and cell lines. Macrophages are peculiar in the… Expand
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