tetrahydrobiopterin biosynthetic process

Known as: tetrahydrobiopterin formation, tetrahydrobiopterin synthesis, tetrahydrobiopterin biosynthesis 
The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
051019782018

Papers overview

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2008
2008
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
OBJECTIVE HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for… (More)
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Highly Cited
2007
Highly Cited
2007
Regulation of tetrahydrobiopterin biosynthesis by shear stress.
An essential cofactor for the endothelial NO synthase is tetrahydrobiopterin (H4B). In the present study, we show that in human… (More)
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Highly Cited
2004
Highly Cited
2004
Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
OBJECTIVE Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features… (More)
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Highly Cited
2002
Highly Cited
2002
Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
The present study was designed to investigate the interaction between 5-methyltetrahydrofolate and tetrahydrobiopterin in… (More)
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Highly Cited
2001
Highly Cited
2001
L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin.
Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion… (More)
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Highly Cited
1996
Highly Cited
1996
Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport.
The cytokine-inducible isoform of nitric oxide synthase (iNOS or NOS2) plays an important role in the immune response to some… (More)
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Highly Cited
1995
Highly Cited
1995
Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries.
BACKGROUND The L-arginine/nitric oxide pathway plays a key role in the regulation of arterial tone. Biosynthesis of nitric oxide… (More)
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Highly Cited
1994
Highly Cited
1994
Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase…
We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h… (More)
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Highly Cited
1993
Highly Cited
1993
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
Stimulation of nitric oxide (NO) synthase in endothelial cells by Ca2+ influx leads to increased intracellular levels of cGMP. NO… (More)
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1990
1990
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts
The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with… (More)
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