A. Bacher

Publications699
h-index69
Citations20,477
Highly Influential Citations649
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Analysis of a chemical plant defense mechanism in grasses.
TLDR
Five genes, Bx1 through Bx5, are required for DIBOA biosynthesis in maize and the functions of these five genes, clustered on chromosome 4, were demonstrated in vitro. Expand
Biosynthesis of isoprenoids via the non-mevalonate pathway
TLDR
The mevalonate pathway is essential in plants, many eubacteria and apicomplexan parasites, but not in archaea and animals, and detailed knowledge about the mechanisms may benefit the development of novel antibiotics, antimalarials and herbicides. Expand
Deoxyxylulose phosphate pathway to terpenoids.
Recently, a mevalonate-independent pathway was discovered in bacteria and plants that leads to the formation of isopentenyl diphosphate and dimethylallyl diphosphate, the two basic precursors of… Expand
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms.
Recent studies have uncovered the existence of an alternative, non-mevalonate pathway for the formation of isopentenyl pyrophosphate and dimethylallyl pyrophosphate, the two building blocks of… Expand
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and IspH protein
TLDR
A recombinant fusion protein comprising maltose binding protein and IspG protein domains was purified from a recombinant Escherichia coli strain and found that auxiliary proteins are required as shuttles for redox equivalents. Expand
Studies on the nonmevalonate pathway to terpenes: The role of the GcpE (IspG) protein
Recombinant Escherichia coli cells engineered for the expression of the xylB gene in conjunction with genes of the nonmevalonate pathway were supplied with 13C-labeled 1-deoxy-d-xylulose. Cell… Expand
Probing the reaction mechanism of IspH protein by x-ray structure analysis
TLDR
The five crystal structures of IspH in complex with substrate, converted substrate, products and PPi reported in this article provide unique insights into the mechanism of this enzyme. Expand
Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement.
TLDR
13C Enrichment and 13C13C coupling patterns showed conclusively that 1-deoxy-D-xylulose and not mevalonate is the predominant isoprenoid precursor of phytol, beta-carotene, and lutein. Expand
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.
TLDR
It is shown that an enzyme isolated from cell extract of Escherichia coli converts 2-C-methylerythritol 4-phosphate into 4-diphosphocytidyl-2-C and ygbP by reaction with CTP, suggesting that both the YgbP protein and the ygbB protein are involved in the deoxyxylulose pathway. Expand
Zinc plays a key role in human and bacterial GTP cyclohydrolase I.
TLDR
The crystal structure of recombinant human GTP cyclohydrolase I was solved by Patterson search methods by using the coordinates of the Escherichia coli enzyme as a model to contain an essential zinc ion coordinated to a His side chain. Expand
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