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tesmilifene

Known as: DEPMPE, DPPE, N,N-diethyl-2-(4-(phenylmethyl)phenoxy)ethanamine 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Histamine AntagonistsPhenyl EthersPlatelet Aggregation Inhibitors
cyclophosphamide/tesmilifenedoxorubicin/tesmilifene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third-generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose.
BACKGROUND/AIM Eribulin mesylate, also called Halaven® (HAL), was recently developed as a microtubule-targeting drug and is used… 
2015
2015
Tesmilifene modifies brain endothelial functions and opens the blood–brain/blood–glioma barrier
Tesmilifene, a tamoxifen analog with antihistamine action, has chemopotentiating properties in experimental and clinical cancer… 
Highly Cited
2014
Highly Cited
2014
Copper-catalyzed borylative allyl-allyl coupling reaction.
Borylative allyl-allyl coupling using allenes, bis(pinacolato)diboron, and allyl phosphates has been developed in the presence of… 
Highly Cited
2014
Highly Cited
2014
Phosphinogold(I) Dithiocarbamate Complexes: Effect of the Nature of Phosphine Ligand on Anticancer Properties
The reactions of potassium salts of the dithiocarbamates L {where L = pyrazolyldithiocarbamate (L1), 3,5… 
Review
2012
Review
2012
Cancer stem cells and novel targets for antitumor strategies.
Cancer stem cells (CSCs) were identified in human leukemias in landmark studies of John Dick and his colleagues. Subsequently… 
2010
2010
Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P‐glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats
Objectives  It has been reported that docetaxel is a P‐glycoprotein substrate and is metabolized via the cytochrome P450 (CYP) 3A… 
2009
2009
Preferential Killing of Breast Tumor Initiating Cells by N,N-Diethyl-2-[4-(Phenylmethyl)Phenoxy]Ethanamine/Tesmilifene
Purpose:N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE; tesmilifene) is thought to potentiate the antineoplastic effect… 
2006
2006
Quality of Life Analyses in a Clinical Trial of DPPE (tesmilifene) Plus Doxorubicin Versus Doxorubicin in Patients with Advanced or Metastatic Breast Cancer: NCIC CTG Trial MA.19
BackgroundDPPE (tesmilifene) plus doxorubicin (DOX) demonstrated a significant improvement in survival versus DOX in a phase III… 
2005
2005
Phase II trial of tesmilifene plus mitoxantrone and prednisone for hormone refractory prostate cancer: high subjective and objective response in patients with symptomatic metastases.
PURPOSE Symptomatic, hormone refractory prostate cancer (HRCAP) is a major cause of morbidity with a median survival of less than… 
Highly Cited
2004
Highly Cited
2004
Phase III study of N,N-diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine (BMS-217380-01) combined with doxorubicin versus doxorubicin alone in metastatic/recurrent breast cancer: National Cancer…
PURPOSE N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE; tesmilifene) is a novel agent that augments chemotherapy… 
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