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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
Mice deficient for the RB gene (RB-/-), prior to death at embryonic day 14.5, show increased cell death in all tissues that normally express RB1: the nervous system, liver, lens, and skeletal muscleExpand
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The retinoblastoma gene family is differentially expressed during embryogenesis
We report differential expression of the RB1 tumor suppressor gene and the homologous genes p107 and p130 during embryogenesis. Abundant RB1 transcripts were detected during neurogenesis,Expand
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Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
BACKGROUND Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma suppressor gene initiatesExpand
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The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
Precursors of cochlear and vestibular hair cells of the inner ear exit the cell cycle at midgestation. Hair cells are mitotically quiescent during late-embryonic differentiation stages andExpand
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Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors.
A variety of human malignancies, including breast cancer, are thought to be organized in a hierarchy, whereby a relatively minor population of tumor initiating cells (TIC) is responsible for tumorExpand
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Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.
PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one of the most frequently mutated genes in human breast cancer. Here, we describe a mouse model forExpand
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A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.
The retinoblastoma gene product, p110RB1, appears to regulate cell growth by modulating the activities of nuclear transcription factors. The elements that specify the transport of p110RB1 into theExpand
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Stra13 Homodimers Repress Transcription through Class B E-box Elements*
A mammalian basic helix-loop-helix protein known variably as Stra13, Sharp2, and Dec1 has been implicated in cell activation, proliferation, and differentiation. Indeed,Stra13 null mice developExpand
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RB1 and p53 at the crossroad of EMT and triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease that includes Basal-like and Claudin-low tumors. The Claudin-low tumors are enriched for features associated withExpand
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