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tepoxalin

Known as: 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Anti-Inflammatory Agents, Non-SteroidalImmunosuppressive AgentsPyrazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Acute and chronic effects of tepoxalin on kidney function in dogs with chronic kidney disease and osteoarthritis.
OBJECTIVE To determine whether tepoxalin alters kidney function in dogs with chronic kidney disease (CKD). ANIMALS 16 dogs with… 
2009
2009
Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model.
BACKGROUND Little is known about the effect of dual cyclooxygenase (COX) and lipoxygenase inhibition on canine gastric mucosal… 
2005
2005
Effect of tepoxalin on renal function in healthy dogs receiving an angiotensin-converting enzyme inhibitor.
The objective of this study was to investigate renal function in clinically normal dogs receiving tepoxalin, a nonsteroidal… 
2004
2004
Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin H2 synthase-2.
2000
2000
Tepoxalin inhibits inflammation and microvascular dysfunction induced by abdominal irradiation in rats
Inflammatory cells contribute to the acute and sub‐acute sequelae of radiation therapy. Tepoxalin, an inhibitor of cyclooxygenase… 
1996
1996
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac‐1 and E‐selectin expression
Inflammation is characterized by the migration of polymorphonuclear leukocytes from the vasculature into the tissue causing… 
1996
1996
Pharmacokinetics and Pharmacodynamics of Tepoxalin after Single Oral Dose Administration to Healthy Volunteers
This study was conducted to examine the pharmacokinetics and pharmacodynamics of tepoxalin in healthy volunteers, an… 
1996
1996
Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs.
Tepoxalin [5- (4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole -3-propanamide] is an orally active anti… 
Highly Cited
1995
Highly Cited
1995
Tepoxalin, a Novel Dual Inhibitor of the Prostaglandin-H Synthase Cyclooxygenase and Peroxidase Activities (*)
Prostaglandin-H synthase-1, the rate-limiting enzyme in prostaglandin synthesis, has both cyclooxygenase (CO) and peroxidase (PO… 
1994
1994
Tepoxalin, a novel immunosuppressive agent with a different mechanism of action from cyclosporin A.
Tepoxalin, a compound previously identified as a dual cyclooxygenase/lipoxygenase (CO/LO) inhibitor, is a potent inhibitor of T… 
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