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taxane 10-beta-hydroxylase activity

Known as: taxane 10b-hydroxylase activity, taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating), 5-alpha-taxadienol-10-beta-hydroxylase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O… Expand
National Institutes of Health

Papers overview

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2017
2017
Anti-Müllerian hormone (AMH) levels in premenopausal breast cancer patients treated with taxane-based adjuvant chemotherapy - A translational research project of the SUCCESS A study.
BACKGROUND Premenopausal women undergoing chemotherapy are at high risk for premature ovarian failure and its long-term… Expand
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2015
2015
Stabilization of Microtubules by Taxane Diterpenoids: Insight from Docking and MD simulations
Microtubules are formed from the molecules of tubulin, whose dynamics is important for many functions in a cell, the most… Expand
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2013
2013
Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.
Five taxane diterpenoids derived from the 95% ethanol extract of Taxus chinensis were tested for the inhibitory activities on… Expand
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2011
2011
Catechin production in cultured cells of Taxus cuspidata and Taxus baccata
The main polyphenols in callus and cell suspension cultures of Taxus cuspidata and T. baccata were (+)-catechin and… Expand
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2005
2005
-Tubulin and to Overcome Paclitaxel Resistance β The Seco-Taxane IDN5390 Is Able to Target Class III
A prominent mechanism of drug resistance to taxanes is the overexpression of class III B-tubulin. The seco-taxane IDN5390 was… Expand
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2004
2004
The seco-taxane IDN5390 is able to target class III beta-tubulin and to overcome paclitaxel resistance.
A prominent mechanism of drug resistance to taxanes is the overexpression of class III beta-tubulin. The seco-taxane IDN5390 was… Expand
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2004
2004
Absorption, distribution, and excretion of DJ-927, a novel orally effective taxane, in mice, dogs, and monkeys.
DJ-927, currently undergoing Phase I clinical trial, is a new orally effective taxane with potent antitumor effects. The… Expand
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2002
2002
Cellular bases of the antitumor activity of the novel taxane IDN 5109 (BAY59-8862) on hormone-refractory prostate cancer.
Taxane-based therapies appear to have a significant efficacy in clinical trials on hormone-refractory prostate carcinoma. In the… Expand
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2002
2002
Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis.
Three new C-14 oxygenated taxane-type diterpenes, hongdoushans A-C (1-3), were isolated from the wood of Taxus yunnanensis… Expand
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2000
2000
A differential scanning calorimetry study of phosphocholines mixed with paclitaxel and its bromoacylated taxanes.
High sensitivity differential scanning calorimetry (DSC) was used to investigate the thermotropic phase properties of binary… Expand
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