FAQ

taxane 10-beta-hydroxylase activity

Known as: taxane 10b-hydroxylase activity, taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating), 5-alpha-taxadienol-10-beta-hydroxylase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
012319902017

Papers overview

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2015
2015
Stabilization of microtubules by taxane diterpenoids: insight from docking and MD simulations.
Microtubules are formed from the molecules of tubulin, whose dynamics is important for many functions in a cell, the most… (More)
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2006
2006
Reversal of adverse effects of neoadjuvant chemotherapy on bone turnover in pre- and post-menopausal women with zoledronic acid.
556 Background: Ovarian failure secondary to adjuvant chemotherapy is known to have an adverse effect on bone mineral density and… (More)
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2004
2004
Phase IB and pharmacological study of the novel taxane BMS-184476 in combination with doxorubicin.
The aim of this study was to define the maximum tolerated dose (MTD) and the pharmacological profile of the paclitaxel analogue… (More)
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2002
2002
Acute cardiac tolerance of current contrast media and the new taxane protaxel using iopromide as carrier during porcine coronary angiography and stenting.
RATIONALE AND OBJECTIVES The systemic tolerance thresholds of modern low-osmolar x-ray contrast media (CM) are similarly high… (More)
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2002
2002
Two new rearranged taxoids from Taxus wallichiana ZUCC.
Two new rearranged taxane diterpenoids, 5alpha,7beta,10beta,13alpha-tetrahydroxy-2alpha,9alpha,15-triacetoxy-11(15-->1)-abeo-taxa… (More)
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2001
2001
Taxol biosynthesis: Taxane 13 -hydroxylase is a cytochrome P450-dependent monooxygenase
A central feature in the biosynthesis of Taxol is oxygenation at multiple positions of the taxane core structure, reactions that… (More)
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2000
2000
A differential scanning calorimetry study of phosphocholines mixed with paclitaxel and its bromoacylated taxanes.
High sensitivity differential scanning calorimetry (DSC) was used to investigate the thermotropic phase properties of binary… (More)
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1999
1999
A new taxoid, 19-acetoxytaxagifine, from Taxus chinensis.
A new taxane diterpene, 19-acetoxytaxagifine (1), was isolated from an ethanol extract of the aerial parts of Taxus chinensis… (More)
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1997
1997
Preparation of a C-1 Oxygenated Taxane A Ring via a Highly Efficient Diels-Alder Strategy Utilizing an alpha-(Aroyloxy) Enone Captodative Dienophile.
 
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1990
1990
New Taxanes from Taxus chinensis.
Two new taxane diterpenes, decinnamoyltaxagifine ( 3) and decinnanioyltaxagifine acetate ( 2), have been isolated from the leaves… (More)
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