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taxane 10-beta-hydroxylase activity

Known as: taxane 10b-hydroxylase activity, taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating), 5-alpha-taxadienol-10-beta-hydroxylase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O… Expand
National Institutes of Health

Papers overview

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2017
2017
BACKGROUND Premenopausal women undergoing chemotherapy are at high risk for premature ovarian failure and its long-term… Expand
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2015
2015
Microtubules are formed from the molecules of tubulin, whose dynamics is important for many functions in a cell, the most… Expand
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2013
2013
Five taxane diterpenoids derived from the 95% ethanol extract of Taxus chinensis were tested for the inhibitory activities on… Expand
Highly Cited
2005
Highly Cited
2005
A prominent mechanism of drug resistance to taxanes is the overexpression of class III beta-tubulin. The seco-taxane IDN5390 was… Expand
2004
2004
DJ-927, currently undergoing Phase I clinical trial, is a new orally effective taxane with potent antitumor effects. The… Expand
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2002
2002
Taxane-based therapies appear to have a significant efficacy in clinical trials on hormone-refractory prostate carcinoma. In the… Expand
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2002
2002
Five new taxane diterpenoids, taxumairols G (1), H (2), I (3), J (4), and L (5) were isolated from extracts of the roots of… Expand
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2001
2001
A 4(20),11(12)-taxadiene derivative was converted to hydroxylated derivatives by Cunninghamella elegans AS3.2033 and… Expand
Highly Cited
2000
Highly Cited
2000
High sensitivity differential scanning calorimetry (DSC) was used to investigate the thermotropic phase properties of binary… Expand
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