taxane 10-beta-hydroxylase activity

Known as: taxane 10b-hydroxylase activity, taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating), 5-alpha-taxadienol-10-beta-hydroxylase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
012319902017

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2015
2015
Microtubules are formed from the molecules of tubulin, whose dynamics is important for many functions in a cell, the most… (More)
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2006
2006
556 Background: Ovarian failure secondary to adjuvant chemotherapy is known to have an adverse effect on bone mineral density and… (More)
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2004
2004
The aim of this study was to define the maximum tolerated dose (MTD) and the pharmacological profile of the paclitaxel analogue… (More)
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2002
2002
RATIONALE AND OBJECTIVES The systemic tolerance thresholds of modern low-osmolar x-ray contrast media (CM) are similarly high… (More)
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2002
2002
Two new rearranged taxane diterpenoids, 5alpha,7beta,10beta,13alpha-tetrahydroxy-2alpha,9alpha,15-triacetoxy-11(15-->1)-abeo-taxa… (More)
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2001
2001
A central feature in the biosynthesis of Taxol is oxygenation at multiple positions of the taxane core structure, reactions that… (More)
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2000
2000
High sensitivity differential scanning calorimetry (DSC) was used to investigate the thermotropic phase properties of binary… (More)
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1999
1999
A new taxane diterpene, 19-acetoxytaxagifine (1), was isolated from an ethanol extract of the aerial parts of Taxus chinensis… (More)
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1990
1990
Two new taxane diterpenes, decinnamoyltaxagifine ( 3) and decinnanioyltaxagifine acetate ( 2), have been isolated from the leaves… (More)
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