Y. Tezuka

Publications375
h-index61
Citations12,797
Highly Influential Citations412
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Recent progress in pharmacological research of propolis
TLDR
This review article compiles recent findings (since 1995) on the pharmacological properties of propolis focusing on its antihepatotoxic, antitumour, antioxidative, antimicrobial and antiinflammatory properties.
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IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT
TLDR
Results indicate that gomisin C is a mechanism-based inhibitor that not only competitively inhibits but irreversibly inactivates CYP3A4.
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Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship.
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Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum.
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Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
TLDR
Investigation of the mechanism of action of arctigenin revealed that the compound blocked the activation of Akt induced by glucose starvation, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.
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Cytotoxic, hepatoprotective and free radical scavenging effects of propolis from Brazil, Peru, the Netherlands and China.
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Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.
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Constituents of the Vietnamese medicinal plant Orthosiphon stamineus.
TLDR
All the isolated compounds were tested for their cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, and the new diterpenes, except for 4, and flavonoids showed cytot toxicity with an ED50 value between 10 and 90 microg/ml.
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Chemical constituents of Brazilian propolis and their cytotoxic activities.
The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2, 2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds,…
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Constituents of Chinese propolis and their antiproliferative activities.
TLDR
Two new flavonoids, 3-O-[(S)-2-methylbutyroyl]pinobanksin and 6-cinnamylchrysin, were isolated from the EtOAc-soluble fraction of the MeOH extract of Chinese propolis, along with 12 known compounds, and showed potent antiproliferative activity toward tested cell lines.
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