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New cyclic peptide assemblies with hydrophobic cavities: the structural and thermodynamic basis of a new class of peptide nanotubes.
A new class of self-assembling peptides based on cyclic peptides made of alternating 3-aminocyclohexanecarboxylic acid (gamma-Acc) and alpha-amino acids is described. The studied cylindricalExpand
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Large-diameter self-assembled dimers of alpha,gamma-cyclic peptides, with the nanotubular solid-state structure of cyclo-[(l-Leu-D-(Me)N-gamma-Acp)(4)-].4CHCl(2)COOH.
Dimeric nanotube segments with pore diameters of up to 17 A have been obtained by self-assembly from new alpha,gamma-cyclic peptides.
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A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
The synthesis of high-affinity reversible competitive inhibitors of Mycobacterium tuberculosis type II dehydroquinase, an essential enzyme in Mycobacterium tuberculosis bacteria, is reported. TheExpand
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Efficient Palladium-Catalyzed Cyclotrimerization of Arynes: Synthesis of Triphenylenes.
Found at the core of many discotic liquid crystals, triphenylenes can now be synthesized efficiently by the palladium-catalyzed trimerization of arynes, including those containing donor and acceptorExpand
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Inhibition of calcium entry induced by cularines and isocrasifoline in uterine smooth muscle.
The effects of nifedipine, papaverine and four benzylisoquinoline alkaloids (cularine, cularidine, celtisine and isocrasifoline) were studied in isolated rat uterus in order to clarify the mechanismExpand
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Alpha,gamma-peptide nanotube templating of one-dimensional parallel fullerene arrangements.
The formation and full characterization of single self-assembling alpha,gamma-peptide nanotubes (alpha,gamma-SPNs) is described. The introduction of C(60) into cyclic peptides allows the preparationExpand
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Electron transfer in Me-blocked heterodimeric α,γ-peptide nanotubular donor–acceptor hybrids
Bio-inspired cyclopeptidic heterodimers built on β-sheet-like hydrogen-bonding networks and bearing photoactive and electroactive chromophores on the outer surface have been prepared. DifferentExpand
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Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies
Several 3‐heteroaryl analogs of the known dehydroquinase inhibitor (1R,4R,5R)‐1,4,5‐trihydroxy‐2‐cyclohexene‐1‐carboxylic acid (4) were synthesized and tested as inhibitors of Helicobacter pyloriExpand
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