Skip to search formSkip to main contentSkip to account menu

tautomycetin

Known as: (17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxo-nonadeca-16,18-dien-2-yl) 3-hydroxy-3-(4-methyl-2,5-dioxo-3-furyl)-propanoate 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

FuransLipids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412
Tautomycetin (TMC) is a linear polyketide metabolite produced by Streptomyces sp. CK4412 that has been reported to possess… 
2013
2013
Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells.
Tautomycetin (TMC), originally isolated from Streptomyces griseochromogenes, has been suggested as a potential drug retaining… 
2010
2010
Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.
The biosynthetic gene cluster for tautomycetin (TTN), a highly potent and selective protein phosphatase (PP) inhibitor isolated… 
2009
2009
Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412
Comparative transcriptome analysis has revealed several acidic pH shock-induced genes presumably involved with stimulation of… 
2008
2008
Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.
Tautomycetin (TMC) is a novel activated T-cell-specific immunosuppressive compound with a unique structure, containing an ester… 
2008
2008
Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation.
TNFalpha activated NF-kappaB and associated regulatory factors including IKK are strongly implicated in a variety of… 
2006
2006
Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal–regulated kinase pathway
Tautomycetin is an antifungal antibiotic retaining potent immunosuppressive function. We have identified the roles of… 
Highly Cited
2002
Highly Cited
2002
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction
Tautomycetin (TMC) was identified as an immunosuppressor of activated T cells. Inhibition of T cell proliferation with TMC was… 
1992
1992
Tautomycetin suppresses the TNFα/NF-κB pathway via inhibition of IKK activation
TNFalpha activated NF-kappaB and associated regulatory factors including IKK are strongly implicated in a variety of… 
1990
1990
The structure of tautomycetin, a dialkylmaleic anhydride antibiotic.
The chemical structure of tautomycetin (C33H50O10) was determined by chemical degradation and spectroscopic evidence… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)