Share This Author
Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase
- H. Shima, M. Pende, Yi Chen, S. Fumagalli, G. Thomas, S. Kozma
- BiologyThe EMBO journal
- 16 November 1998
It is demonstrated that homozygous disruption of the p70s 6k/p85s6k gene does not affect viability or fertility of mice, but that it has a significant effect on animal growth, especially during embryogenesis, and the finding of a new S6 kinase gene, which can partly compensate for p70S6k/ p85s 6K function, underscores the importance of S6K function in cell growth.
Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
- S. Mitsuhashi, N. Matsuura, M. Ubukata, H. Oikawa, H. Shima, K. Kikuchi
- Biology, ChemistryBiochemical and biophysical research…
- 21 September 2001
TC is the most specific PP1 inhibitor out of over 40 species of natural phosphatase inhibitors reported, strongly suggesting that TC is a novel powerful tool to elucidate the physiological roles of PP1 in various biological events.
Molecular phylogeny of the subfamily Exoristinae (Diptera, Tachinidae), with discussions on the evolutionary history of female oviposition strategy
The transformation of female reproductive habits in the Exoristinae is evaluated, finding support for the hypothesis that ovolarviparity evolved independently from oviparity in several clades, and obtaining different results concerning the evolutionary history of micro‐ovolarvIParity depending on character optimization.
Aurora-B associated protein phosphatases as negative regulators of kinase activation
The present study shows that human Aurora-B is activated by okadaic acid and forms complexes with the protein serine/threonine phosphatase type 1 (PP1) or PP2A, but not with PP5, and finds that this enzyme is an arginine-directed kinase that can phosphorylate histone H3 at serines 10 and 28 in vitro, suggesting that human aurora is a mitotic hist one H3 kinase.
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition
It is reported that stimulation of epithelial–mesenchymal transition (EMT) results in the nuclear translocation of PKM2 in colon cancer cells, which is pivotal in promoting EMT.
MKP-7, a Novel Mitogen-activated Protein Kinase Phosphatase, Functions as a Shuttle Protein*
- K. Masuda, H. Shima, Masahiko Watanabe, K. Kikuchi
- BiologyThe Journal of Biological Chemistry
- 19 October 2001
Co-immunoprecipitation experiments and histological analysis suggested that MKP-7 determines the localization of MAPKs in the cytoplasm, and these findings indicate that MKp-7 is the first identified leptomycin B-sensitive shuttle MKP.
Identification of Members of the Protein Phosphatase 1 Gene Family in the Rat and Enhanced Expression of Protein Phosphatase 1α Gene in Rat Hepatocellular Carcinomas
- K. Sasaki, H. Shima, Y. Kitagawa, S. Irino, T. Sugimura, M. Nagao
- Biology, ChemistryJapanese journal of cancer research : Gann
- 1 December 1990
Four kinds of cDNA clones of isotypes of catalytic subunits of protein phosphatase 1 (PP‐1) from rat liver and testis cDNA libraries were isolated, and several amino acids located in the middle regions of the peptides were conserved in all the isotypes.
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.
Scapinin, a Putative Protein Phosphatase-1 Regulatory Subunit Associated with the Nuclear Nonchromatin Structure*
The results suggest that scapinin is a putative regulatory subunit of PP1 and is involved in transformed or immature phenotypes of HL-60 cells and the presence of scapInin family proteins from worm to human is described.
Annotated catalogue of the Tachinidae (Insecta: Diptera) of China
The Tachinidae of mainland China and Taiwan (generally referred to as China herein for brevity) are catalogued and two genera and 23 species are recorded as misidentified from China.