FAQ

talabostat

Known as: [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid, valinyl-boroproline 
A small molecule with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat… (More)

Topic mentions per year

Topic mentions per year

2006-2018
02420062018

Related topics

Related topics

4 relations

Broader (2)

Boronic AcidsDipeptides

Narrower (2)

PT 100PT-100 dipeptide

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
talabostat
Dipeptides
Boronic Acids
PT 100
PT-100 dipeptide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Fibroblast activation protein (FAP) as a novel metabolic target
OBJECTIVE Fibroblast activation protein (FAP) is a serine protease belonging to a S9B prolyl oligopeptidase subfamily. This… (More)
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2011
2011
Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions
Fibroblast activation protein-α (FAP) is a cell surface, serine protease of the post-prolyl peptidase family that is expressed in… (More)
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2009
2009
Phase II trial of talabostat and docetaxel in advanced non-small cell lung cancer.
AIMS Currently available therapies do improve survival in advanced stage non-small cell lung cancer (NSCLC), but only to a… (More)
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2008
2008
Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma
Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl… (More)
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2008
2008
HIV-1 Env vaccine comprised of electroporated DNA and protein co-administered with Talabostat.
Selection of potent yet low reactogenic adjuvants for protein immunization is important for HIV-1 vaccine development… (More)
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2007
2007
Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer.
PURPOSE Fibroblast Activation Protein (FAP) is a tumor fibroblast protease that has been shown to potentiate colorectal cancer… (More)
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Review
2007
Review
2007
Talabostat.
Talabostat mesilate is an orally active, specific inhibitor of dipeptidyl peptidases, including tumor-associated fibroblast… (More)
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2006
2006
Phase 2 trial of talabostat and cisplatin in patients with stage IV melanoma.
8040 Background: Talabostat (TAL) is an oral inhibitor of dipeptidyl peptidases such as fibroblast activation protein found on… (More)
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2006
2006
Phase II study of talabostat and rituximab in fludarabine/rituximab-resistant or refractory patients with CLL.
6598 Background: Talabostat (TAL) is an orally administered small molecule inhibitor of dipeptidyl peptidases such as CD26 and… (More)
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2006
2006
Reduction of murine osteosarcoma lung metastases using the dipeptidyl peptidase inhibitor talabostat.
9009 Background: Dipeptidyl peptidases comprise a family of serine proteases that includes the genes dipeptidyl peptidase IV (DPP… (More)
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