t(1;19)

A cytogenetic abnormality that involves a translocation between chromosomes 1 and 19.
National Institutes of Health

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2 relations
Chromosomes, Human, Pair 1Chromosomes, Human, Pair 19

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Highly Cited
2012
Highly Cited
2012
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.
We report that t(1;19) ALL cells universally exhibit expression of and dependence on the cell surface receptor ROR1. We further… (More)
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Highly Cited
2006
Highly Cited
2006
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma.
Combined deletion of chromosomes 1p and 19q is associated with improved prognosis and responsiveness to therapy in patients with… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
The Wnt family of secreted glycoproteins is widely involved in cell proliferation, differentiation and oncogenesis. Many Wnt… (More)
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Review
1999
Review
1999
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease
Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia patients have shown that large-scale MRD… (More)
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Highly Cited
1991
Highly Cited
1991
The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.
The t(1;19) translocation that characterizes 25% of pediatric pre-B cell acute lymphoblastic leukemias (pre-B ALL) produces a… (More)
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Highly Cited
1990
Highly Cited
1990
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all
It was previously shown that the chromosome 19 breakpoint of the t(1;19)(q23;p13.3) translocation, found in human pre-B cell… (More)
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Highly Cited
1990
Highly Cited
1990
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
The gene (E2A) for enhancer binding transcription factors E12 and E47 maps to the t(1;19) chromosomal translocation breakpoint in… (More)
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Highly Cited
1990
Highly Cited
1990
Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study.
The prognostic significance of chromosomal translocations, particularly t(1;19) (q23;p13), was evaluated in children with pre-B… (More)
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Highly Cited
1990
Highly Cited
1990
Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19).
In earlier studies of the cytogenetic characteristics of leukemic lymphoblasts from children with pre-B-cell acute lymphoblastic… (More)
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Highly Cited
1984
Highly Cited
1984
Pre-B cell leukemia associated with chromosome translocation 1;19.
Chromosome banding studies on 60 children with acute lymphocytic leukemia (ALL), including "null," pre-B, B, and T cell… (More)
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