t(1;19)

We report that t(1;19) ALL cells universally exhibit expression of and dependence on the cell surface receptor ROR1. We further… Expand

Combined deletion of chromosomes 1p and 19q is associated with improved prognosis and responsiveness to therapy in patients with… Expand

Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia patients have shown that large-scale MRD… Expand

The t(1;19)(q23;p13) translocation occurs in approximately 5% of B-precursor acute lymphoblastic leukemias (ALLs) occurring in… Expand

The t(1;19) translocation that characterizes 25% of pediatric pre-B cell acute lymphoblastic leukemias (pre-B ALL) produces a… Expand

The gene (E2A) for enhancer binding transcription factors E12 and E47 maps to the t(1;19) chromosomal translocation breakpoint in… Expand

It was previously shown that the chromosome 19 breakpoint of the t(1;19)(q23;p13.3) translocation, found in human pre-B cell… Expand

In earlier studies of the cytogenetic characteristics of leukemic lymphoblasts from children with pre-B-cell acute lymphoblastic… Expand

The prognostic significance of chromosomal translocations, particularly t(1;19) (q23;p13), was evaluated in children with pre-B… Expand

The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to… Expand