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Pathology and genetics of tumours of soft tissue and bone
1. Adipocytic tumours 2. Fibroblastic/Myofibroblastic tumours 3. So-called fibrohistiocytic tumours 4. Smooth muscle tumours 5. Pericytic (perivascular) tumours 6. Skeletal muscle tumours 7. VascularExpand
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. InExpand
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The impact of translocations and gene fusions on cancer causation
Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337Expand
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The emerging complexity of gene fusions in cancer
Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have providedExpand
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Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics
Solitary fibrous tumor (SFT) is composed of spindled to ovoid cells in a patternless architecture with prominent stromal collagen and hemangiopericytoma-like vessels. Some tumors showExpand
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A breakpoint map of recurrent chromosomal rearrangements in human neoplasia
Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have beenExpand
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Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents
Purpose: High-grade osteosarcoma is a malignant primary bone tumor with a peak incidence in adolescence. Overall survival (OS) of patients with resectable metastatic disease is approximately 20%. TheExpand
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Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer
Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have beenExpand
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Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in humanExpand
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