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Shifts in cadherin profiles between human normal melanocytes and melanomas.
The results suggest downregulation of E-cadherin but upregulation of N-c cadherin in melanoma cells, which may endow melanocytic cells with new adhesive properties and altered spatial relations that favor uncontrolled proliferation, migration, and invasion.
N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells.
Results indicate that the cadherin subtype switching from E- to N-cadherin during melanoma development not only frees melanocytic cells from the control by keratinocytes but also provides growth and possibly metastatic advantages to melanoma cells.
Colorectal carcinoma antigens detected by hybridoma antibodies
Hybridoma cells which secrete colorectal carcinoma-specific antibodies have been produced and used to study the antigenic structure of these tumor cells, and several antigens with distinct molecular characteristics have been shown to exist by use of hybridoma antibodies.
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.
Constutively activated ERK is identified in almost all melanoma cell lines and in tumor tissues tested, which is in contrast to normal melanocytes and several early stage radial growth phase melanoma lines where ERK can be activated by serum or growth factors.
Suppression of BRAF(V599E) in human melanoma abrogates transformation.
Activating mutations in the BRAF serine/threonine kinase are found in >70% of human melanomas, of which >90% are BRAF(V599E). We sought to investigate the role of the BRAF(V599E) allele in malignant
Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.
Two hybridomas and their clones secreted antibodies binding specifically to human colorectal carcinoma cells either grown in culture or obtained from patients, but did not bind to normal colonic mucosa or other normal and malignant human cells.
Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.
The distribution of integrin adhesion receptors was examined in benign and malignant lesions of human melanocytes and in tissue sections from benign to increasingly malignant melanocytic lesions using a panel of monoclonal antibodies against specific integrin subunits to examine the presence of this integrin.
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.
A reverse transcription-polymerase chain reaction assay is used to analyze expression of the MAGE-1 gene by cell lines from different types of tumors, melanomas from different stages of disease progression, normal diploid cell lines, and melanocyte and nevus tissue from which malignant melanomas are derived.
Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck.
VEGF expression and MVD were directly associated with tumor aggressiveness in experimental tumors and suggest a role for VEGF in both clinical and experimental HNSCC.