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sulindac sulfide

Known as: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid, 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-(4-(methylthio)phenyl)methylene-, (Z)- 
The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a… 
National Institutes of Health

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5 relations

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsSulindacTocolytic Agents
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations
Sulindac is a non-selective inhibitor of cyclooxygenases (COX) used to treat inflammation and pain. Additionally, non-COX targets… 
2006
2006
Mitochondrial uncoupling by the sulindac metabolite, sulindac sulfide.
Sulindac is a non-steroidal antiinflammatory drug (NSAID) known to inhibit cyclooxygenases (COX) 1 and 2, and at present of… 
2006
2006
Id‐1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer
The molecular mechanisms underlying the chemopreventive effects of NSAIDs are not well understood and remain the subject of… 
2005
2005
Genetic Polymorphisms of Flavin Monooxygenase 3 in Sulindac-Induced Regression of Colorectal Adenomas in Familial Adenomatous Polyposis
Sulindac is a nonsteroidal antiinflammatory drug with a chemopreventive effect in patients with familial adenomatous polyposis… 
2005
2005
Sulindac sulfide–induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) that induces apoptosis in cultured colon cancer cells and in intestinal… 
Highly Cited
2003
Highly Cited
2003
The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species.
2003
2003
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Colorectal cancer is the second leading cause of cancer death in the United States. Nonsteroidal anti-inflammatory drugs… 
1990
1990
Effects of sulindac and naproxen on prostaglandin excretion in patients with impaired renal function and rheumatoid arthritis.
Highly Cited
1986
Highly Cited
1986
Sulindac reduces the urinary excretion of prostaglandins and impairs renal function in cirrhosis with ascites.
In 5 patients with cirrhosis and ascites the glomerular filtration rate (GFR), free water clearance (CH2O) and urinary excretion… 
Highly Cited
1985
Highly Cited
1985
Sulindac is not renal sparing in man
We investigated the claimed renal‐sparing effect of the cyclooxygenase inhibitor sulindac. Fifteen normal women following a diet… 
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