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sulindac sulfide

Known as: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid, 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-(4-(methylthio)phenyl)methylene-, (Z)- 
The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a… 
National Institutes of Health

Related topics

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5 relations

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsSulindacTocolytic Agents
analogs & derivatives

Papers overview

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2019
2019
Abstract P6-22-01: Repurposing sulindac sulfide as a notch inhibitor to target cancer stem-like cells in triple negative breast cancer
Triple negative breast cancer (TNBC) is a heterogeneous group of clinically aggressive breast cancers. TNBC patients have a high… 
2008
2008
An Essential Protein Repair Enzyme: Investigation of the Molecular Recognition Mechanism of Methionine Sulfoxide Reductase A
  • J. So
  • 2008
  • Corpus ID: 82754231
Abstract : The amino acid methionine is particularly sensitive to damage by reactive oxygen species. The enzyme methionine… 
2008
2008
Inhibition of cyclooxygenase -2 and amphiregulin reduces cell proliferation in a colorectal cancer cell line
Background: The role of cyclooxygenase-2 (COX-2) overexpression in colorectal cancers has engaged interest in the role of COX-2… 
2006
2006
Sulfone Metabolite of Sulindac Inhibits Mammary Carcinogenesis 1
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the… 
2004
2004
Celecoxib and sulindac sulfide enhance the cytotoxic effect of standard chemotherapeutic agents and possess anti-tumor activity mediated by p21cipl/waf1 expression
3186 Background: Standard treatment modalities for head and neck cancer remain surgery, radiation, and chemotherapy. While… 
2000
2000
Influence of Kras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and Difluoromethylornithine 1
The nonsteroidal anti-inflammatory drug sulindac and the ornithine decarboxylase inhibitor difluoromethylornithine (DFMO) are… 
1988
1988
Pharmacokinetics of sulindac in ESRD.
Charles J. Diskin, MD, Opelika Nephrology Referral Center, Inc., 122 North 20th Street, Opelika, AL 36802 (USA) Dear Sir We would… 
1987
1987
Prostaglandin and thromboxane synthesis by highly enriched rabbit proximal tubular cells in culture.
Prostaglandin synthetic profiles were studied in monolayers of highly enriched rabbit renal proximal tubular cells cultured in… 
1986
1986
Inhibition of renal prostaglandin synthesis in man: methodological and clinical implications.
Integrity of renal prostaglandin synthesis is necessary to maintain renal cortical and medullary function in patients with kidney… 
1984
1984
Pharmacokinetics of graded oral doses of sulindac in man.
Pharmacokinetics of graded doses of sulindac were studied on 9 healthy volunteers. Serum concentrations of sulindac (inactive…