The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species.

@article{Fernandes2003TheMO,
  title={The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species.},
  author={Eduarda Fernandes and Sofia A Toste and Jos{\'e} Lu{\'i}s Costa Lima and Salette Reis},
  journal={Free radical biology & medicine},
  year={2003},
  volume={35 9},
  pages={
          1008-17
        }
}
  • Eduarda Fernandes, Sofia A Toste, +1 author Salette Reis
  • Published in
    Free radical biology…
    2003
  • Chemistry, Medicine
  • Sulindac is a sulfoxide prodrug that, in vivo, is converted to the metabolites sulindac sulfide and sulindac sulfone. It is therapeutically used as an anti-inflammatory and analgesic in the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. In addition to its anti-inflammatory properties, sulindac and its metabolites have been shown to have an important role in the prevention of colonic carcinogenesis. Although the inhibition of… CONTINUE READING

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